Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation

Tuhin Subhra Santra; Pen Cheng Wang; Hwan You Chang; Fan Gang Tseng

doi:10.1063/1.4833535

Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation

Tuhin Subhra Santra, Pen Cheng Wang, Hwan You Chang, Fan Gang Tseng

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

Interaction of electric field with biological cells is an important phenomenon for field induced drug delivery system. We demonstrate a selective and localized single cell nano-electroporation (LSCNEP) by applying an intense electric field on a submicron region of the single cell membrane, which can effectively allow high efficient molecular delivery but low cell damage. The delivery rate is controlled by adjusting transmembrane potential and manipulating membrane status. Thermal and ionic influences are deteriorated from the cell membrane by dielectric passivation. Either reversible or irreversible by LSCNEP can fully controlled with potential applications in medical diagnostics and biological studies.

Original language	English
Article number	233701
Journal	Applied Physics Letters
Volume	103
Issue number	23
DOIs	https://doi.org/10.1063/1.4833535
State	Published - 02 12 2013
Externally published	Yes

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abstract = "Interaction of electric field with biological cells is an important phenomenon for field induced drug delivery system. We demonstrate a selective and localized single cell nano-electroporation (LSCNEP) by applying an intense electric field on a submicron region of the single cell membrane, which can effectively allow high efficient molecular delivery but low cell damage. The delivery rate is controlled by adjusting transmembrane potential and manipulating membrane status. Thermal and ionic influences are deteriorated from the cell membrane by dielectric passivation. Either reversible or irreversible by LSCNEP can fully controlled with potential applications in medical diagnostics and biological studies.",

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AU - Chang, Hwan You

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AB - Interaction of electric field with biological cells is an important phenomenon for field induced drug delivery system. We demonstrate a selective and localized single cell nano-electroporation (LSCNEP) by applying an intense electric field on a submicron region of the single cell membrane, which can effectively allow high efficient molecular delivery but low cell damage. The delivery rate is controlled by adjusting transmembrane potential and manipulating membrane status. Thermal and ionic influences are deteriorated from the cell membrane by dielectric passivation. Either reversible or irreversible by LSCNEP can fully controlled with potential applications in medical diagnostics and biological studies.

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Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation

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