Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.

Hui Chi Huang; Ming Kuem Lin; Syh Yuan Hwang; Tsong Long Hwang; Yao Haur Kuio; Chi I. Chang; Chung Yi Ou; Yueh Hsiung Kuo

doi:10.3390/molecules18088752

Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.

Hui Chi Huang
, Ming Kuem Lin
, Syh Yuan Hwang
, Tsong Long Hwang
, Yao Haur Kuio
, Chi I. Chang
, Chung Yi Ou
, Yueh Hsiung Kuo^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

China Medical University Taichung
Council of Agriculture Taiwan
National Research Institute of Chinese Medicine Taiwan
National Pingtung University of Science and Technology

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds 3-10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.

Original language	English
Pages (from-to)	8752-8763
Number of pages	12
Journal	Molecules
Volume	18
Issue number	8
DOIs	https://doi.org/10.3390/molecules18088752
State	Published - 08 2013

Keywords

Agavaceae
Anti-inflammatory activity
Dracaena angustifolia Roxb
Drangustosides A-B
Steroidal saponins

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10.3390/molecules18088752

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title = "Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.",

abstract = "Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds 3-10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.",

keywords = "Agavaceae, Anti-inflammatory activity, Dracaena angustifolia Roxb, Drangustosides A-B, Steroidal saponins",

author = "Huang, \{Hui Chi\} and Lin, \{Ming Kuem\} and Hwang, \{Syh Yuan\} and Hwang, \{Tsong Long\} and Kuio, \{Yao Haur\} and Chang, \{Chi I.\} and Ou, \{Chung Yi\} and Kuo, \{Yueh Hsiung\}",

year = "2013",

month = aug,

doi = "10.3390/molecules18088752",

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volume = "18",

pages = "8752--8763",

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issn = "1420-3049",

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TY - JOUR

T1 - Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.

AU - Huang, Hui Chi

AU - Lin, Ming Kuem

AU - Hwang, Syh Yuan

AU - Hwang, Tsong Long

AU - Kuio, Yao Haur

AU - Chang, Chi I.

AU - Ou, Chung Yi

AU - Kuo, Yueh Hsiung

PY - 2013/8

Y1 - 2013/8

N2 - Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds 3-10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.

AB - Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds 3-10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.

KW - Agavaceae

KW - Anti-inflammatory activity

KW - Dracaena angustifolia Roxb

KW - Drangustosides A-B

KW - Steroidal saponins

UR - https://www.scopus.com/pages/publications/84883189663

U2 - 10.3390/molecules18088752

DO - 10.3390/molecules18088752

M3 - 文章

C2 - 23887717

AN - SCOPUS:84883189663

SN - 1420-3049

VL - 18

SP - 8752

EP - 8763

JO - Molecules

JF - Molecules

IS - 8

ER -

Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb.

Abstract

Keywords

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