Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

Chi Lok Wong; Ho Pui Ho; Kin Fong Lei; Wen Jung Li; Kwok Sum Chan; Wing Cheung Law; Shu Yuen Wu; Siu Kai Kong; Chinlon Lin

doi:10.1109/EDSSC.2005.1635374

Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

Chi Lok Wong
, Ho Pui Ho
, Kin Fong Lei
, Wen Jung Li
, Kwok Sum Chan
, Wing Cheung Law
, Shu Yuen Wu
, Siu Kai Kong
, Chinlon Lin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.

Original language	English
Title of host publication	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	709-712
Number of pages	4
ISBN (Print)	0780393392, 9780780393394
DOIs	https://doi.org/10.1109/EDSSC.2005.1635374
State	Published - 2005
Externally published	Yes
Event	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC - Howloon, Hong Kong Duration: 19 12 2005 → 21 12 2005

Publication series

Name	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC

Conference

Conference	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
Country/Territory	Hong Kong
City	Howloon
Period	19/12/05 → 21/12/05

Access to Document

10.1109/EDSSC.2005.1635374

Cite this

Wong, C. L., Ho, H. P., Lei, K. F., Li, W. J., Chan, K. S., Law, W. C., Wu, S. Y., Kong, S. K., & Lin, C. (2005). Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. In 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC (pp. 709-712). Article 1635374 (2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EDSSC.2005.1635374

Wong, Chi Lok ; Ho, Ho Pui ; Lei, Kin Fong et al. / Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC. Institute of Electrical and Electronics Engineers Inc., 2005. pp. 709-712 (2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC).

@inproceedings{cd1bacbe1821424595cf2d1aec31adf1,

title = "Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform",

abstract = "The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.",

author = "Wong, \{Chi Lok\} and Ho, \{Ho Pui\} and Lei, \{Kin Fong\} and Li, \{Wen Jung\} and Chan, \{Kwok Sum\} and Law, \{Wing Cheung\} and Wu, \{Shu Yuen\} and Kong, \{Siu Kai\} and Chinlon Lin",

year = "2005",

doi = "10.1109/EDSSC.2005.1635374",

language = "英语",

isbn = "0780393392",

series = "2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "709--712",

booktitle = "2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC",

address = "美国",

note = "2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC ; Conference date: 19-12-2005 Through 21-12-2005",

}

Wong, CL, Ho, HP, Lei, KF, Li, WJ, Chan, KS, Law, WC, Wu, SY, Kong, SK & Lin, C 2005, Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. in 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC., 1635374, 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC, Institute of Electrical and Electronics Engineers Inc., pp. 709-712, 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC, Howloon, Hong Kong, 19/12/05. https://doi.org/10.1109/EDSSC.2005.1635374

Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. / Wong, Chi Lok; Ho, Ho Pui; Lei, Kin Fong et al.
2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC. Institute of Electrical and Electronics Engineers Inc., 2005. p. 709-712 1635374 (2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

AU - Wong, Chi Lok

AU - Ho, Ho Pui

AU - Lei, Kin Fong

AU - Li, Wen Jung

AU - Chan, Kwok Sum

AU - Law, Wing Cheung

AU - Wu, Shu Yuen

AU - Kong, Siu Kai

AU - Lin, Chinlon

PY - 2005

Y1 - 2005

N2 - The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.

AB - The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.

UR - https://www.scopus.com/pages/publications/43549087170

U2 - 10.1109/EDSSC.2005.1635374

DO - 10.1109/EDSSC.2005.1635374

M3 - 会议稿件

AN - SCOPUS:43549087170

SN - 0780393392

SN - 9780780393394

T3 - 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC

SP - 709

EP - 712

BT - 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC

Y2 - 19 December 2005 through 21 December 2005

ER -

Wong CL, Ho HP, Lei KF, Li WJ, Chan KS, Law WC et al. Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. In 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC. Institute of Electrical and Electronics Engineers Inc. 2005. p. 709-712. 1635374. (2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC). doi: 10.1109/EDSSC.2005.1635374

Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

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