Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Yi Ching Lee, Ho Chang Kuo, Jeng Sheng Chang, Luan Yin Chang, Li Min Huang, Ming Ren Chen, Chi Di Liang, Hsin Chi, Fu Yuan Huang, Meng Luen Lee, Yhu Chering Huang, Betau Hwang, Nan Chang Chiu, Kao Pin Hwang, Pi Chang Lee, Li Ching Chang, Yi Min Liu, Ying Ju Chen, Chien Hsiun Chen, Yuan Tsong Chen*Fuu Jen Tsai, Jer Yuarn Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

168 Scopus citations

Abstract

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

Original languageEnglish
Pages (from-to)522-525
Number of pages4
JournalNature Genetics
Volume44
Issue number5
DOIs
StatePublished - 05 2012

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