Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Yi Ching Lee; Ho Chang Kuo; Jeng Sheng Chang; Luan Yin Chang; Li Min Huang; Ming Ren Chen; Chi Di Liang; Hsin Chi; Fu Yuan Huang; Meng Luen Lee; Yhu Chering Huang; Betau Hwang; Nan Chang Chiu; Kao Pin Hwang; Pi Chang Lee; Li Ching Chang; Yi Min Liu; Ying Ju Chen; Chien Hsiun Chen; Yuan Tsong Chen; Fuu Jen Tsai; Jer Yuarn Wu

doi:10.1038/ng.2227

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Yi Ching Lee
, Ho Chang Kuo
, Jeng Sheng Chang
, Luan Yin Chang
, Li Min Huang
, Ming Ren Chen
, Chi Di Liang
, Hsin Chi
, Fu Yuan Huang
, Meng Luen Lee
, Yhu Chering Huang
, Betau Hwang
, Nan Chang Chiu
, Kao Pin Hwang
, Pi Chang Lee
, Li Ching Chang
, Yi Min Liu
, Ying Ju Chen
, Chien Hsiun Chen
, Yuan Tsong Chen^*

Fuu Jen Tsai, Jer Yuarn Wu

^*Corresponding author for this work

School of Medicine

Academia Sinica - Institute of Biomedical Sciences
National Tsing Hua University
China Medical University Taichung
National Taiwan University
Mackay Memorial Hospital Taiwan
Chang Gung Memorial Hospital
Chang Gung University
Changhua Christian Hospital
Taipei City Hospital
Veterans General Hospital-Taipei
Duke University
Asia University Taiwan

Research output: Contribution to journal › Journal Article › peer-review

185 Scopus citations

Abstract

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 ^-8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

Original language	English
Pages (from-to)	522-525
Number of pages	4
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2227
State	Published - 05 2012

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Lee, Y. C., Kuo, H. C., Chang, J. S., Chang, L. Y., Huang, L. M., Chen, M. R., Liang, C. D., Chi, H., Huang, F. Y., Lee, M. L., Huang, Y. C., Hwang, B., Chiu, N. C., Hwang, K. P., Lee, P. C., Chang, L. C., Liu, Y. M., Chen, Y. J., Chen, C. H., ... Wu, J. Y. (2012). Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nature Genetics, 44(5), 522-525. https://doi.org/10.1038/ng.2227

@article{502b25934e2c4927ad75d3c77bb8a900,

title = "Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis",

abstract = "To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.",

author = "Lee, \{Yi Ching\} and Kuo, \{Ho Chang\} and Chang, \{Jeng Sheng\} and Chang, \{Luan Yin\} and Huang, \{Li Min\} and Chen, \{Ming Ren\} and Liang, \{Chi Di\} and Hsin Chi and Huang, \{Fu Yuan\} and Lee, \{Meng Luen\} and Huang, \{Yhu Chering\} and Betau Hwang and Chiu, \{Nan Chang\} and Hwang, \{Kao Pin\} and Lee, \{Pi Chang\} and Chang, \{Li Ching\} and Liu, \{Yi Min\} and Chen, \{Ying Ju\} and Chen, \{Chien Hsiun\} and Chen, \{Yuan Tsong\} and Tsai, \{Fuu Jen\} and Wu, \{Jer Yuarn\}",

year = "2012",

month = may,

doi = "10.1038/ng.2227",

language = "英语",

volume = "44",

pages = "522--525",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Lee, YC, Kuo, HC, Chang, JS, Chang, LY, Huang, LM, Chen, MR, Liang, CD, Chi, H, Huang, FY, Lee, ML, Huang, YC, Hwang, B, Chiu, NC, Hwang, KP, Lee, PC, Chang, LC, Liu, YM, Chen, YJ, Chen, CH, Chen, YT, Tsai, FJ & Wu, JY 2012, 'Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis', Nature Genetics, vol. 44, no. 5, pp. 522-525. https://doi.org/10.1038/ng.2227

TY - JOUR

T1 - Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

AU - Lee, Yi Ching

AU - Kuo, Ho Chang

AU - Chang, Jeng Sheng

AU - Chang, Luan Yin

AU - Huang, Li Min

AU - Chen, Ming Ren

AU - Liang, Chi Di

AU - Chi, Hsin

AU - Huang, Fu Yuan

AU - Lee, Meng Luen

AU - Huang, Yhu Chering

AU - Hwang, Betau

AU - Chiu, Nan Chang

AU - Hwang, Kao Pin

AU - Lee, Pi Chang

AU - Chang, Li Ching

AU - Liu, Yi Min

AU - Chen, Ying Ju

AU - Chen, Chien Hsiun

AU - Chen, Yuan Tsong

AU - Tsai, Fuu Jen

AU - Wu, Jer Yuarn

PY - 2012/5

Y1 - 2012/5

N2 - To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

AB - To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

UR - https://www.scopus.com/pages/publications/84862814732

U2 - 10.1038/ng.2227

DO - 10.1038/ng.2227

M3 - 文章

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AN - SCOPUS:84862814732

SN - 1061-4036

VL - 44

SP - 522

EP - 525

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

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