Type 2 diabetes mellitus increases peritonsillar abscess susceptibility: Real-world evidence

Ching Lung Wu, Ming Shao Tsai, Ta Jen Lee, Yun Ting Wang, Chia Yen Liu, Yao Hsu Yang, Yao Te Tsai, Cheng Ming Hsu, Ching Yuan Wu, Pey Jium Chang, Geng He Chang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations


Objectives. Type 2 diabetes mellitus (T2DM) is a risk factor for deep neck infection (DNI) and leads to complications and poor outcomes. Our study aimed to investigate the risk, prognosis, and complications of peritonsillar abscess (PTA) in patients with T2DM. Methods. We extracted data of patients newly diagnosed as having T2DM between January 2000 and December 2011 from Taiwan’s National Health Insurance Research Database. These patients were matched with patients without T2DM, and PTA incidence was compared between both cohorts. Results. In total, 67,852 patients with and 135,704 patients without T2DM were enrolled. PTA incidence was significantly higher in patients with T2DM (incidence rate ratio, 1.91; P<0.001); moreover, PTA incidence was higher at 1 to 5 years after T2DM diagnosis than at <1 and >5 years after T2DM diagnosis. Cox regression analysis showed that patients with T2DM had an approximately 2-fold higher PTA risk (adjusted hazard ratio [aHR]: 1.89, P<0.001). Patients with a higher adapted Diabetes Complications Severity Index (aDCSI) had higher PTA risk than those with a lower aDC-SI (aHRs: 2.17 for aDCSI ≥1, P=0.006 and 1.81 for aDCSI=0, P=0.002). T2DM patients with a high aDCSI (≥1) had a nonsignificantly longer hospitalization duration and a higher rate of DNI complications than did those with a low aDCSI (=0). Conclusion. In patients with T2DM, PTA incidence was relatively high, and it increased with T2DM severity. Moreover, T2DM patients should be particularly careful about PTA within 1 to 5 years after the diagnosis, and physicians should keep in mind that the prognosis of PTA was correlated with T2DM severity.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalClinical and Experimental Otorhinolaryngology
Issue number3
StatePublished - 08 2021

Bibliographical note

Publisher Copyright:
© 2021 by Korean Society of Otorhinolaryngology-Head and Neck Surgery.


  • Diabetes Complications Severity Index
  • Hyperglycemia
  • Peritonsillar Abscess
  • Quinsy
  • Type 2 Diabetes Mellitus


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