Ultra high phase sensitive surface plasmon resonance biosensor

Ying Chang Li, Chien Chou*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study demonstrates a novel phase-sensitive surface plasman resonance biosensor (PS-SPRB) which is able to convert the phase modulation into amplitude modulation analytically via a differential amplifier. PS-SPRB is able to measure biomolecule interactions at ultra-low concentration relying on the properties of phase sensitive detection at shot-noise detection in a real-time. The common-phase noise-rejection mode is provided in PS-SPRB to be able to immune the background phase noise efficiently. The experimental results confirm the detection sensitivity of 0.00001 wt % concentration of sucrose solution and 10 fg/ml mouse IgG interaction with anti IgG in real time.

Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing IX
DOIs
StatePublished - 2009
EventOptical Diagnostics and Sensing IX - San Jose, CA, United States
Duration: 26 01 200927 01 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7186
ISSN (Print)1605-7422

Conference

ConferenceOptical Diagnostics and Sensing IX
Country/TerritoryUnited States
CitySan Jose, CA
Period26/01/0927/01/09

Keywords

  • Biomolecular interaction
  • Biosensor
  • Heterodyne
  • Phase sensitive
  • Surface plasmon resonance (SPR)
  • Surface plasmon wave (SPW)

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