Umbilical cord blood immunology-relevance to stem cell transplantation

Syh Jae Lin; Dah Chin Yan; Yen Chang Lee; Hsiu Shan Hsiao; Pei Tzu Lee; Yu Wen Liang; Ming Ling Kuo

doi:10.1007/s12016-011-8289-4

Umbilical cord blood immunology-relevance to stem cell transplantation

Syh Jae Lin, Dah Chin Yan, Yen Chang Lee, Hsiu Shan Hsiao, Pei Tzu Lee, Yu Wen Liang, Ming Ling Kuo^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

15 Scopus citations

Abstract

Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.

Original language	English
Pages (from-to)	45-57
Number of pages	13
Journal	Clinical Reviews in Allergy and Immunology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/s12016-011-8289-4
State	Published - 02 2012

Keywords

Dendritic cells
Natural killer cells
Regulatory T cells
Stem cell transplantation
T cells
Umbilical cord blood

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10.1007/s12016-011-8289-4

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abstract = "Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naivet{\'e} of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.",

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AU - Lin, Syh Jae

AU - Yan, Dah Chin

AU - Lee, Yen Chang

AU - Hsiao, Hsiu Shan

AU - Lee, Pei Tzu

AU - Liang, Yu Wen

AU - Kuo, Ming Ling

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AB - Because of its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem cell transplantation. Naiveté of UCB lymphocytes, however, results in delayed immune reconstitution and infection-related mortality in transplant recipients. This review updates the phenotypic and functional deficiencies of various immune cell populations in UCB compared with their adult counterparts and discusses clinical implications and possible therapeutic strategies to improve the outcome of stem cell transplantation.

KW - Dendritic cells

KW - Natural killer cells

KW - Regulatory T cells

KW - Stem cell transplantation

KW - T cells

KW - Umbilical cord blood

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Umbilical cord blood immunology-relevance to stem cell transplantation

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Keywords

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