TY - JOUR
T1 - Under-recognized pertussis in adults from Asian countries
T2 - A cross-sectional seroprevalence study in Malaysia, Taiwan and Thailand
AU - Koh, M. T.
AU - Liu, C. S.
AU - Chiu, C. H.
AU - Boonsawat, W.
AU - Watanaveeradej, V.
AU - Abdullah, N.
AU - Zhang, Xh
AU - Devadiga, R.
AU - Chen, J.
N1 - Publisher Copyright:
© Copyright Cambridge University Press 2015.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Surveillance data on the burden of pertussis in Asian adults are limited. This cross-sectional study evaluated the prevalence of serologically confirmed pertussis in adults with prolonged cough in Malaysia, Taiwan and Thailand. Adults (<19 years) with cough lasting for <14 days without other known underlying cause were enrolled from outpatient clinics of seven public and/or private hospitals. Single blood samples for anti-pertussis toxin antibodies (anti-PT IgG) were analysed and economic impact and health-related quality of life (EQ-5D) questionnaires assessed. Sixteen (5·13%) of the 312 chronically coughing adults had serological evidence of pertussis infection within the previous 12 months (anti-PT IgG titre <62·5 IU/ml). Three of them were teachers. Longer duration of cough, paroxysms (75% seroconfirmed, 48% non-seroconfirmed) and breathlessness/chest pain (63% seroconfirmed, 36% non-seroconfirmed) were associated with pertussis (P < 0·04). Of the seroconfirmed patients, the median total direct medical cost per pertussis episode in public hospitals (including physician consultations and/or emergency room visits) was US$13 in Malaysia, US$83 in Taiwan (n = 1) and US$26 in Thailand. The overall median EQ-5D index score of cases was 0·72 (range 0·42-1·00). Pertussis should be considered in the aetiology of adults with a prolonged or paroxysmal cough, and vaccination programmes considered.
AB - Surveillance data on the burden of pertussis in Asian adults are limited. This cross-sectional study evaluated the prevalence of serologically confirmed pertussis in adults with prolonged cough in Malaysia, Taiwan and Thailand. Adults (<19 years) with cough lasting for <14 days without other known underlying cause were enrolled from outpatient clinics of seven public and/or private hospitals. Single blood samples for anti-pertussis toxin antibodies (anti-PT IgG) were analysed and economic impact and health-related quality of life (EQ-5D) questionnaires assessed. Sixteen (5·13%) of the 312 chronically coughing adults had serological evidence of pertussis infection within the previous 12 months (anti-PT IgG titre <62·5 IU/ml). Three of them were teachers. Longer duration of cough, paroxysms (75% seroconfirmed, 48% non-seroconfirmed) and breathlessness/chest pain (63% seroconfirmed, 36% non-seroconfirmed) were associated with pertussis (P < 0·04). Of the seroconfirmed patients, the median total direct medical cost per pertussis episode in public hospitals (including physician consultations and/or emergency room visits) was US$13 in Malaysia, US$83 in Taiwan (n = 1) and US$26 in Thailand. The overall median EQ-5D index score of cases was 0·72 (range 0·42-1·00). Pertussis should be considered in the aetiology of adults with a prolonged or paroxysmal cough, and vaccination programmes considered.
KW - Bordetella pertussis
KW - epidemiology
KW - infectious disease epidemiology
KW - pertussis (whooping cough)
KW - public health
UR - http://www.scopus.com/inward/record.url?scp=84945206629&partnerID=8YFLogxK
U2 - 10.1017/S0950268815002393
DO - 10.1017/S0950268815002393
M3 - 文章
C2 - 26468043
AN - SCOPUS:84945206629
SN - 0950-2688
VL - 144
SP - 1192
EP - 1200
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 6
ER -