Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Lin Chen Ho; Chao Hsiung Hsu; Chung Mao Ou; Chia Wei Wang; Tsang Pai Liu; Lian Pin Hwang; Yung Ya Lin; Huan Tsung Chang

doi:10.1016/j.biomaterials.2014.10.006

Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Lin Chen Ho, Chao Hsiung Hsu, Chung Mao Ou, Chia Wei Wang, Tsang Pai Liu, Lian Pin Hwang, Yung Ya Lin, Huan Tsung Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd³⁺ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r₁=0.9 and 14.5mm^-1s^-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping.

Original language	English
Pages (from-to)	436-446
Number of pages	11
Journal	Biomaterials
Volume	37
DOIs	https://doi.org/10.1016/j.biomaterials.2014.10.006
State	Published - 01 01 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

Keywords

Core-shell
Drug delivery
Magnetic resonance imaging (MRI)
Nanoparticle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2014.10.006

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abstract = "Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1=0.9 and 14.5mm-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping.",

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AU - Liu, Tsang Pai

AU - Hwang, Lian Pin

AU - Lin, Yung Ya

AU - Chang, Huan Tsung

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AB - Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1=0.9 and 14.5mm-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping.

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Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging

Abstract

Bibliographical note

Keywords

UN SDGs

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