TY - JOUR
T1 - Unveiling roles of beneficial gut bacteria and optimal diets for health
AU - Kumar, Suresh
AU - Mukherjee, Riya
AU - Gaur, Pratibha
AU - Leal, Élcio
AU - Lyu, Xiaoming
AU - Ahmad, Saheem
AU - Puri, Paridhi
AU - Chang, Chung Ming
AU - Raj, V. Samuel
AU - Pandey, Ramendra Pati
N1 - Copyright © 2025 Kumar, Mukherjee, Gaur, Leal, Lyu, Ahmad, Puri, Chang, Raj and Pandey.
PY - 2025
Y1 - 2025
N2 - The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial gut bacteria such as Akkermansia muciniphila, Adlercreutzia equolifaciens, and Christensenella minuta contribute to metabolic regulation and immune support through bioactive metabolites like short-chain fatty acids (SCFAs). Dietary patterns rich in prebiotics, fermented foods, and plant-based bioactive compounds, including polyphenols and flavonoids, promote microbiome diversity and stability. However, challenges such as individual variability, bioavailability, dietary adherence, and the dynamic nature of the gut microbiota remain significant. This review synthesizes current insights into gut bacteria’s role in health, emphasizing the mechanisms by which dietary interventions modulate microbiota. Additionally, it highlights advancements in microbiome-targeted therapies and the transformative potential of personalized nutrition, leveraging microbiota profiling and artificial intelligence (AI) to develop tailored dietary strategies for optimizing gut health and mitigating chronic inflammatory disorders. Addressing these challenges requires a multidisciplinary approach that integrates scientific innovation, ethical frameworks, and practical implementation strategies.
AB - The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial gut bacteria such as Akkermansia muciniphila, Adlercreutzia equolifaciens, and Christensenella minuta contribute to metabolic regulation and immune support through bioactive metabolites like short-chain fatty acids (SCFAs). Dietary patterns rich in prebiotics, fermented foods, and plant-based bioactive compounds, including polyphenols and flavonoids, promote microbiome diversity and stability. However, challenges such as individual variability, bioavailability, dietary adherence, and the dynamic nature of the gut microbiota remain significant. This review synthesizes current insights into gut bacteria’s role in health, emphasizing the mechanisms by which dietary interventions modulate microbiota. Additionally, it highlights advancements in microbiome-targeted therapies and the transformative potential of personalized nutrition, leveraging microbiota profiling and artificial intelligence (AI) to develop tailored dietary strategies for optimizing gut health and mitigating chronic inflammatory disorders. Addressing these challenges requires a multidisciplinary approach that integrates scientific innovation, ethical frameworks, and practical implementation strategies.
KW - fatty acid
KW - healthy gut bacteria
KW - phytochemicals
KW - prebiotic foods and probiotic foods
KW - probiotics
UR - http://www.scopus.com/inward/record.url?scp=86000464378&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2025.1527755
DO - 10.3389/fmicb.2025.1527755
M3 - 文献综述
C2 - 40041870
AN - SCOPUS:86000464378
SN - 1664-302X
VL - 16
SP - 1527755
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 1527755
ER -