Uric acid as a predictor for early allograft dysfunction after living donor liver transplantation: A prospective observational study

Li Min Hu; Hsin I. Tsai; Chao Wei Lee; Hui Ming Chen; Wei Chen Lee; Huang Ping Yu

doi:10.3390/jcm10122729

Uric acid as a predictor for early allograft dysfunction after living donor liver transplantation: A prospective observational study

Li Min Hu, Hsin I. Tsai, Chao Wei Lee, Hui Ming Chen, Wei Chen Lee, Huang Ping Yu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.

Original language	English
Article number	2729
Journal	Journal of Clinical Medicine
Volume	10
Issue number	12
DOIs	https://doi.org/10.3390/jcm10122729
State	Published - 06 2021

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Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Antioxidant
Early allograft dysfunction
Liver transplantation
Oxidative stress
Reperfusion injury
Uric acid
Uric acid therapy

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@article{819898258c324f6795b27bd1a5851df3,

title = "Uric acid as a predictor for early allograft dysfunction after living donor liver transplantation: A prospective observational study",

abstract = "Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.",

keywords = "Antioxidant, Early allograft dysfunction, Liver transplantation, Oxidative stress, Reperfusion injury, Uric acid, Uric acid therapy",

author = "Hu, {Li Min} and Tsai, {Hsin I.} and Lee, {Chao Wei} and Chen, {Hui Ming} and Lee, {Wei Chen} and Yu, {Huang Ping}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

doi = "10.3390/jcm10122729",

language = "英语",

volume = "10",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

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number = "12",

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TY - JOUR

T1 - Uric acid as a predictor for early allograft dysfunction after living donor liver transplantation

T2 - A prospective observational study

AU - Hu, Li Min

AU - Tsai, Hsin I.

AU - Lee, Chao Wei

AU - Chen, Hui Ming

AU - Lee, Wei Chen

AU - Yu, Huang Ping

PY - 2021/6

Y1 - 2021/6

N2 - Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.

AB - Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.

KW - Antioxidant

KW - Early allograft dysfunction

KW - Liver transplantation

KW - Oxidative stress

KW - Reperfusion injury

KW - Uric acid

KW - Uric acid therapy

UR - http://www.scopus.com/inward/record.url?scp=85114065731&partnerID=8YFLogxK

U2 - 10.3390/jcm10122729

DO - 10.3390/jcm10122729

M3 - 文章

AN - SCOPUS:85114065731

SN - 2077-0383

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 12

M1 - 2729

ER -

Uric acid as a predictor for early allograft dysfunction after living donor liver transplantation: A prospective observational study

Abstract

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