Usage of growth factors in acute muscle injuries

Chih Hwa Chen*, Chian Her Lee, Chih Hsiang Chang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Skeletal muscle injuries are the most common sports-related injuries and present a challenge in primary care and sports medicine. When a skeletal muscle is injured, satellite cells are activated and inflammatory cells migrate to the injury site. Complete recovery from the injury is compromised due to the development of fibrosis. To minimize the disability and enhance full functional recovery after skeletal muscle injuries, growth factors acting on satellite cells and inflammatory cells were developed to promote the regeneration of injured skeletal muscle. To improve injured muscle to recover better or faster, several biological growth factors had been developed, such as exogenous growth factors which would promote healing of injured muscle fibers, the inhibition of which would block the muscle fibrosis. Drugs that inhibit TGF-ß (transforming growth factor-ß) had been developed for clinical use with some good results. More clinical trial was needed for the development of drugs that promote the regeneration of injured skeletal muscle.

Original languageEnglish
Title of host publicationSports Injuries
Subtitle of host publicationPrevention, Diagnosis, Treatment and Rehabilitation, Second Edition
PublisherSpringer Berlin Heidelberg
Number of pages11
ISBN (Electronic)9783642365690
ISBN (Print)9783642365683
StatePublished - 01 01 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2012, 2015, All Rights Reserved.


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