Utility of 18F-fluoride PET/CT and 18F-FDG PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients

Sheng Chieh Chan, Hung Ming Wang, Shu Hang Ng, Cheng Lung Hsu, Yu Jr Lin, Chien Yu Lin, Chun Ta Liao, Tzu Chen Yen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations

Abstract

This study compared the diagnostic accuracy of 18F-FDG PET/CT with that of 18F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. Methods: The study participants underwent 18F-FDG PET/CT and 18F-fluoride PET/CT within 2 wk of each another. Results: A total of 98 bony metastases were found in 18 of our 80 patients. 18F-fluoride PET/CT and 18F-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P = 0.126) and areas under the curve (0.7561 vs. 0.7959, P = 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P < 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients. Conclusion: 18F-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to 18F-FDG PET/CT. Their combined use may not be justifiable. COPYRIGHT

Original languageEnglish
Pages (from-to)1730-1735
Number of pages6
JournalJournal of Nuclear Medicine
Volume53
Issue number11
DOIs
StatePublished - 01 11 2012

Keywords

  • Bony metastases
  • Diagnosis
  • F-FDG
  • F-fluoride
  • Head and neck cancer
  • PET

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