Vagal atrial fibrillation

Yung Hsin Yeh; Kristina Lemola; Stanley Nattel

Vagal atrial fibrillation

Yung Hsin Yeh, Kristina Lemola, Stanley Nattel^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The autonomic nerve system plays an important role in atrial fibrillation (AF). Vagal AF refers AF (generally paroxysmal) arising in contexts of enhanced parasympathetic tone. Heterogeneity of refractoriness and action potential abbreviation resulting from spatially variable parasympathetic enhancement of the acetylcholine-dependent K⁺-current (I_KACh) underlie vagal AF. Adrenergic influences may also contribute to the occurrence of vagal AF. Cholinergic stimulation may enhance ectopic firing from pulmonary vein cardiomyocytes, which potentially contribute to the occurrence of vagal AF. On the other hand, underlying heart disease modulates cholinergic regulation of atrial myocytes. Careful history taking in AF patients is important for vagal AF management. Vagal denervation may play a role in the efficacy of ablation procedures, but the results are conflicting. Specific I_KACh channel blockers may become the treatment of choice in the future.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Acta Cardiologica Sinica
Volume	23
Issue number	1
State	Published - 03 2007

Keywords

Acetylcholine
Muscarinic receptor
Pulmonary vein
Vagal atrial fibrillation
Vagal denervation

Cite this

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title = "Vagal atrial fibrillation",

abstract = "The autonomic nerve system plays an important role in atrial fibrillation (AF). Vagal AF refers AF (generally paroxysmal) arising in contexts of enhanced parasympathetic tone. Heterogeneity of refractoriness and action potential abbreviation resulting from spatially variable parasympathetic enhancement of the acetylcholine-dependent K+-current (IKACh) underlie vagal AF. Adrenergic influences may also contribute to the occurrence of vagal AF. Cholinergic stimulation may enhance ectopic firing from pulmonary vein cardiomyocytes, which potentially contribute to the occurrence of vagal AF. On the other hand, underlying heart disease modulates cholinergic regulation of atrial myocytes. Careful history taking in AF patients is important for vagal AF management. Vagal denervation may play a role in the efficacy of ablation procedures, but the results are conflicting. Specific IKACh channel blockers may become the treatment of choice in the future.",

keywords = "Acetylcholine, Muscarinic receptor, Pulmonary vein, Vagal atrial fibrillation, Vagal denervation",

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AU - Yeh, Yung Hsin

AU - Lemola, Kristina

AU - Nattel, Stanley

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N2 - The autonomic nerve system plays an important role in atrial fibrillation (AF). Vagal AF refers AF (generally paroxysmal) arising in contexts of enhanced parasympathetic tone. Heterogeneity of refractoriness and action potential abbreviation resulting from spatially variable parasympathetic enhancement of the acetylcholine-dependent K+-current (IKACh) underlie vagal AF. Adrenergic influences may also contribute to the occurrence of vagal AF. Cholinergic stimulation may enhance ectopic firing from pulmonary vein cardiomyocytes, which potentially contribute to the occurrence of vagal AF. On the other hand, underlying heart disease modulates cholinergic regulation of atrial myocytes. Careful history taking in AF patients is important for vagal AF management. Vagal denervation may play a role in the efficacy of ablation procedures, but the results are conflicting. Specific IKACh channel blockers may become the treatment of choice in the future.

AB - The autonomic nerve system plays an important role in atrial fibrillation (AF). Vagal AF refers AF (generally paroxysmal) arising in contexts of enhanced parasympathetic tone. Heterogeneity of refractoriness and action potential abbreviation resulting from spatially variable parasympathetic enhancement of the acetylcholine-dependent K+-current (IKACh) underlie vagal AF. Adrenergic influences may also contribute to the occurrence of vagal AF. Cholinergic stimulation may enhance ectopic firing from pulmonary vein cardiomyocytes, which potentially contribute to the occurrence of vagal AF. On the other hand, underlying heart disease modulates cholinergic regulation of atrial myocytes. Careful history taking in AF patients is important for vagal AF management. Vagal denervation may play a role in the efficacy of ablation procedures, but the results are conflicting. Specific IKACh channel blockers may become the treatment of choice in the future.

KW - Acetylcholine

KW - Muscarinic receptor

KW - Pulmonary vein

KW - Vagal atrial fibrillation

KW - Vagal denervation

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M3 - 文献综述

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Vagal atrial fibrillation

Abstract

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