Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour

Manju Chandiramani; Phillip R. Bennett; Richard Brown; Yun S. Lee; David A. Macintyre

doi:10.1017/S0965539514000059

Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour

Manju Chandiramani^*, Phillip R. Bennett, Richard Brown, Yun S. Lee, David A. Macintyre

^*Corresponding author for this work

Imperial College London

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Preterm birth (PTB) has a global prevalence of 11.1% accounting for almost 15 million babies born each year before 37 weeks of gestation. It is a risk factor in over 50% of all neonatal deaths, which amounts to 1.1 million deaths annually. Preterm birth, especially at early gestational ages is associated with a high risk of long-term morbidity in survivors. Despite much research effort, PTB rates continue to rise, placing immense financial and emotional burden on society. In the US, the annual societal economic cost associated with PTB is $26.2 billion with an average of $51,600 being spent per infant born preterm. Preterm labour (PTL) accounts for 70% of these births, of which 25% are preceded by preterm pre-labour rupture of membranes (PPROM).

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Fetal and Maternal Medicine Review
Volume	25
Issue number	1
DOIs	https://doi.org/10.1017/S0965539514000059
State	Published - 17 02 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2014 Cambridge University Press.

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Cite this

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abstract = "Preterm birth (PTB) has a global prevalence of 11.1% accounting for almost 15 million babies born each year before 37 weeks of gestation. It is a risk factor in over 50% of all neonatal deaths, which amounts to 1.1 million deaths annually. Preterm birth, especially at early gestational ages is associated with a high risk of long-term morbidity in survivors. Despite much research effort, PTB rates continue to rise, placing immense financial and emotional burden on society. In the US, the annual societal economic cost associated with PTB is $26.2 billion with an average of $51,600 being spent per infant born preterm. Preterm labour (PTL) accounts for 70% of these births, of which 25% are preceded by preterm pre-labour rupture of membranes (PPROM).",

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Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour

Abstract

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