Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour

Manju Chandiramani*, Phillip R. Bennett, Richard Brown, Yun S. Lee, David A. Macintyre

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Preterm birth (PTB) has a global prevalence of 11.1% accounting for almost 15 million babies born each year before 37 weeks of gestation. It is a risk factor in over 50% of all neonatal deaths, which amounts to 1.1 million deaths annually. Preterm birth, especially at early gestational ages is associated with a high risk of long-term morbidity in survivors. Despite much research effort, PTB rates continue to rise, placing immense financial and emotional burden on society. In the US, the annual societal economic cost associated with PTB is $26.2 billion with an average of $51,600 being spent per infant born preterm. Preterm labour (PTL) accounts for 70% of these births, of which 25% are preceded by preterm pre-labour rupture of membranes (PPROM).

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalFetal and Maternal Medicine Review
Volume25
Issue number1
DOIs
StatePublished - 17 02 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2014 Cambridge University Press.

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