Various clinicopathological features of patients with metachronous colorectal cancer in relation to different diagnostic intervals

Po Yen Lin, Jy Ming Chiang*, Hsin Yun Huang, Jeng Fu You, Sum Fu Chiang, Pao Shiu Hsieh, Chien Yuh Yeh, Rei Ping Tang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations


Backgrounds: Clinicopathologic factors relating to developing metachronous colorectal cancer (CRC) have been reported. However, the effects of different diagnostic intervals on these risk factors required further analysis. Patients and methods: This retrospective study comprised 14,481 patients diagnosed from January 1995 to December 2012. Metachronous CRC was defined as the occurrence of a second colorectal cancer at least 1 year post-operatively. Results: A total of 153 (1.06%) patients developed metachronous CRCs during the follow-up. Significantly higher rates of developing metachronous cancer occurred in male patients (1.2 vs 0.9%), patients with synchronous CRC (2.0 vs 1.0%), and patients with a positive family history of CRC (1.4 vs 0.9%). Pertaining to diagnostic intervals related to clinicopathological features, more severe staging was significant in the diagnostic interval between 2 and 3 years (35 vs 7.7%, 20.6%, 17.5%, P =.01) compared with other intervals. Male patients were more frequently detected to have CRC within 3 years compared with females (53.1 vs 29.1%, P =.005). For a diagnostic interval ≧ 5 years, a significantly higher rate of metachronous CRC located at the right colon was observed than that located at the left colon (36.6 vs 19.7%, p = 0.03). Conclusions: We evinced that a diagnostic interval between 2 and 3 years was a key time for metachronous CRC diagnosis with worse staging distribution. Based on current findings, we recommend the stratification of metachronous CRCs into diagnostic intervals of 1–2, 2–3, and ≧ 3 years, as they exhibit significantly different characteristics.

Original languageEnglish
Pages (from-to)1235-1240
Number of pages6
JournalInternational Journal of Colorectal Disease
Issue number9
StatePublished - 01 09 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.


  • Diagnostic interval
  • Metachronous CRC


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