Vascular Endothelial Growth Factor May Provide Additional Values to C-Reactive Protein and Anti-myeloperoxidase Titer as a Parameter for Evaluating Disease Activity in Anti-myeloperoxidase Associated Vasculitis

Ching Hsiu Peng, Chun Liang Lin*, Chih Wei Yang, Swei Shueh, Chiu Ching Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Anti-myeloperoxidase (anti-MPO) associated vasculitis can result in rapid clinical deterioration. Immunosuppressive therapy is effective but involving considerable toxicity, and disease relapse frequently ensues. Laboratory parameters, such as C-reactive protein and anti-MPO titer, have substantial values in monitoring disease activity. However, the sensitivity and specificity are not satisfactory. This report presents the case of an old man with anti-MPO associated vasculitis. A parallel correlation between serum VEGF levels with C-reactive protein and anti-MPO titer was clearly demonstrated, implying a promising role of VEGF on monitoring disease activity in anti-MPO associated vasculitis. This is the first description of a correlation between VEGF and anti-MPO associated vasculitis.

Original languageEnglish
Pages (from-to)1057-1066
Number of pages10
JournalRenal Failure
Volume25
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Anti-myeloperoxidase (anti-MPO) associated vasculitis
  • Antineutrophil cytoplasmic antibody
  • C-reactive protein
  • Rapid progressive glomerulonephritis
  • Vascular endothelial growth factor (VEGF)

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