Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty

Wen Jin Cherng; Bor Tsung Hsieh; Chao Hung Wang; Ming Jui Hung; K. Y. Cheng; Tsu Tsen Yen; Ning Lee

doi:10.1023/A:1024711224580

Vascular responses to endovascular irradiation of ¹⁸⁸Re in the rabbit model after angioplasty

Wen Jin Cherng, Bor Tsung Hsieh, Chao Hung Wang, Ming Jui Hung, K. Y. Cheng, Tsu Tsen Yen, Ning Lee

Research output: Contribution to journal › Journal Article › peer-review

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Abstract

The effects on vascular restenosis of intravascular radiation delivery from ¹⁸⁸Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radiation on vascular injury in hypercholesterolemic rabbits, thirty rabbits fed with a high cholesterol diet were enrolled into this study. All the rabbits underwent percutaneous transluminal balloon overstretch over left iliac artery. After balloon overstretch, the catheter was withdrawn and immediately followed by irradiation using low dose ¹⁸⁸Re solution (10 Gray) in the vascular wall 0.5 mm distal to intimal surface. After 2 and 6 weeks, arteries were harvested for histological and immunological analysis. This rabbit study suggest that endovascular ¹⁸⁸Re low dose irradiation at the non-injury segment of iliac artery may enhance intima hyperplasia and smooth muscle cell proliferation.

Original language	English
Pages (from-to)	255-260
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	257
Issue number	2
DOIs	https://doi.org/10.1023/A:1024711224580
State	Published - 01 08 2003
Externally published	Yes

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title = "Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty",

abstract = "The effects on vascular restenosis of intravascular radiation delivery from 188Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radiation on vascular injury in hypercholesterolemic rabbits, thirty rabbits fed with a high cholesterol diet were enrolled into this study. All the rabbits underwent percutaneous transluminal balloon overstretch over left iliac artery. After balloon overstretch, the catheter was withdrawn and immediately followed by irradiation using low dose 188Re solution (10 Gray) in the vascular wall 0.5 mm distal to intimal surface. After 2 and 6 weeks, arteries were harvested for histological and immunological analysis. This rabbit study suggest that endovascular 188Re low dose irradiation at the non-injury segment of iliac artery may enhance intima hyperplasia and smooth muscle cell proliferation.",

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AU - Cherng, Wen Jin

AU - Hsieh, Bor Tsung

AU - Wang, Chao Hung

AU - Hung, Ming Jui

AU - Cheng, K. Y.

AU - Yen, Tsu Tsen

AU - Lee, Ning

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AB - The effects on vascular restenosis of intravascular radiation delivery from 188Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radiation on vascular injury in hypercholesterolemic rabbits, thirty rabbits fed with a high cholesterol diet were enrolled into this study. All the rabbits underwent percutaneous transluminal balloon overstretch over left iliac artery. After balloon overstretch, the catheter was withdrawn and immediately followed by irradiation using low dose 188Re solution (10 Gray) in the vascular wall 0.5 mm distal to intimal surface. After 2 and 6 weeks, arteries were harvested for histological and immunological analysis. This rabbit study suggest that endovascular 188Re low dose irradiation at the non-injury segment of iliac artery may enhance intima hyperplasia and smooth muscle cell proliferation.

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Vascular responses to endovascular irradiation of ¹⁸⁸Re in the rabbit model after angioplasty

Abstract

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