Abstract
Because peroxidative damage to red cell membranes may contribute to the pathophysiology of sickle cell disease, deficiency of fat- and water-soluble antioxidants could be a determinant in the pathogenesis of this disease. We have previously reported a deficiency of vitamin E in sickle cell disease. The present study was undertaken to see if a deficiency in vitamin C might also be detected. Leukocyte vitamin C, which reflects total body vitamin C reserve, was measured by a modified 2,4-dinitro-phenylhydrazine method. Sickle cell patients (N = 18) had lower leukocyte vitamin C levels (18.3 ± 9.4 µg/108 cells) than normal controls (N = 12; 30.3 ± 7.5 µg/108 cells; p < 0.01). Furthermore, 50% of the patients had vitamin C levels below 15 µg/108 cells, a value consistent with vitamin C deficiency. A statistically significant correlation (r = −0.62 with 0.01 < p ≤ 0.025) was found between leukocyte vitamin C levels and serum ferritin concentration. Because dietary vitamin C intake appeared to be adequate, increased vitamin C utilization may account for this deficiency. However, the mechanisms for this deficiency as well as its pathophysiologic consequences remain to be established.
Original language | English |
---|---|
Pages (from-to) | 262-267 |
Number of pages | 6 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
Keywords
- Hemoglobinopathies
- Sickle cell anemia
- Vitamin C