Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: A prospective study

I. Hung Shao, Chia Chen Wu, Hsiao Jung Tseng, Ta Jen Lee, Yu Hsiang Lin, Yuan Yun Tam*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Background: Pseudoephedrine is a sympathomimetic drug widely used as a nasal decongestant. However, it can cause adverse effects, such as voiding dysfunction. The risk of voiding dysfunction remains uncertain in patients without subjective voiding problems. Methodology: We prospectively enrolled patients with nasal congestion who required treatment with pseudoephedrine from May to August 2015. All patients denied concomitant subjective voiding problem. The International Prostate Symptom Score (IPSS) questionnaire was used to evaluate voiding function before and 1 week after the pseudoephedrine treatment. The results of the IPSS questionnaire were analyzed as the total (IPSS-T), voiding (IPSS-V), storage (IPSS-S), and quality of life due to urinary symptom scores. Results: We enrolled 131 males with a mean age of 42.0±14.3 years. The IPSS-T, IPSS-V, and IPSS-S scores slightly increased after the medication (IPSS-T increased from 6.49 to 6.77, IPSS-V from 3.33 to 3.53, and IPSS-S from 3.17 to 3.24). The quality of life due to urinary symptom score nonsignificantly decreased from 2.02 to 1.87. We observed that older age and a higher premedication IPSS-V score yielded significant differences (P<0.05) for subclinical voiding dysfunction and unchanged voiding function. In patients aged ≥50 years, the IPSS-T, IPSS-V, and IPSS-S scores significantly increased after the pseudoephedrine treatment (IPSS-T increased from 9.95 to 11.45, IPSS-V from 5.38 to 6.07, and IPSS-S 4.57 to 5.38), whereas the quality of life due to urinary symptom score nonsignificantly decreased from 2.71 to 2.48 (P=0.057). In patients aged <50 years, all scores did not significantly differ. Conclusion: Pseudoephedrine treatment for nasal congestion requires extra precautions in males.50 years, even without subjective voiding symptoms.

Original languageEnglish
Pages (from-to)2333-2339
Number of pages7
JournalDrug Design, Development and Therapy
Volume10
DOIs
StatePublished - 19 07 2016

Bibliographical note

Publisher Copyright:
© 2016 Shao et al.

Keywords

  • IPSS
  • Nasal congestion
  • Pseudoephedrine
  • Voiding dysfunction

Fingerprint

Dive into the research topics of 'Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: A prospective study'. Together they form a unique fingerprint.

Cite this