Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis

Ming Shyan Lin, Tsai Hui Lin, Su Er Guo, Ming Horng Tsai, Ming Shin Chiang, Tung Jung Huang, Mei Yen Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

36 Scopus citations

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents. Methods: This community-based, cross-sectional study ran from December 2012 to September 2013 in southwestern Taiwan. Children <10 and >19 years old, with detected hepatic diseases, or who drank alcohol were excluded. The diagnosis of NAFLD was based on ultrasound: age, sex, anthropometric measurements, and laboratory data were evaluated for associated risks by using logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine cutoff values. Results: We enrolled one thousand, two hundred and ten children (594 males; 616 females; mean age: 15.5 ± 2.8 years). Age, anthropometric measurements, and laboratory data were significantly higher in children with NAFLD. The association between NAFLD and the waist-to-height ratio (WHtR) was significant (adjusted odds ratio: 2.6; 95% confidence interval: 1.909-3.549; P < 0.001). It indicated highly suspicion of NAFLD (sensitivity: 70.1%; specificity 76.9%) when the WHtR for children and adolescents is above the cutoff value of 0.469. Conclusions: The WHtR might be a powerful index of the severity of pediatric NAFLD.

Original languageEnglish
Article number851
JournalBMC Public Health
Volume17
Issue number1
DOIs
StatePublished - 30 10 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

Keywords

  • Childhood obesity
  • cutoff value
  • nonalcoholic fatty liver disease
  • waist-to-height ratio
  • waist-to-hip ratio

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