Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis

Ming Shyan Lin; Tsai Hui Lin; Su Er Guo; Ming Horng Tsai; Ming Shin Chiang; Tung Jung Huang; Mei Yen Chen

doi:10.1186/s12889-017-4868-5

Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis

Ming Shyan Lin, Tsai Hui Lin, Su Er Guo, Ming Horng Tsai, Ming Shin Chiang, Tung Jung Huang, Mei Yen Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

39 Scopus citations

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents. Methods: This community-based, cross-sectional study ran from December 2012 to September 2013 in southwestern Taiwan. Children <10 and >19 years old, with detected hepatic diseases, or who drank alcohol were excluded. The diagnosis of NAFLD was based on ultrasound: age, sex, anthropometric measurements, and laboratory data were evaluated for associated risks by using logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine cutoff values. Results: We enrolled one thousand, two hundred and ten children (594 males; 616 females; mean age: 15.5 ± 2.8 years). Age, anthropometric measurements, and laboratory data were significantly higher in children with NAFLD. The association between NAFLD and the waist-to-height ratio (WHtR) was significant (adjusted odds ratio: 2.6; 95% confidence interval: 1.909-3.549; P < 0.001). It indicated highly suspicion of NAFLD (sensitivity: 70.1%; specificity 76.9%) when the WHtR for children and adolescents is above the cutoff value of 0.469. Conclusions: The WHtR might be a powerful index of the severity of pediatric NAFLD.

Original language	English
Article number	851
Journal	BMC Public Health
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12889-017-4868-5
State	Published - 30 10 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

Keywords

Childhood obesity
cutoff value
nonalcoholic fatty liver disease
waist-to-height ratio
waist-to-hip ratio

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12889-017-4868-5

Cite this

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title = "Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis",

abstract = "Background: Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents. Methods: This community-based, cross-sectional study ran from December 2012 to September 2013 in southwestern Taiwan. Children <10 and >19 years old, with detected hepatic diseases, or who drank alcohol were excluded. The diagnosis of NAFLD was based on ultrasound: age, sex, anthropometric measurements, and laboratory data were evaluated for associated risks by using logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine cutoff values. Results: We enrolled one thousand, two hundred and ten children (594 males; 616 females; mean age: 15.5 ± 2.8 years). Age, anthropometric measurements, and laboratory data were significantly higher in children with NAFLD. The association between NAFLD and the waist-to-height ratio (WHtR) was significant (adjusted odds ratio: 2.6; 95% confidence interval: 1.909-3.549; P < 0.001). It indicated highly suspicion of NAFLD (sensitivity: 70.1%; specificity 76.9%) when the WHtR for children and adolescents is above the cutoff value of 0.469. Conclusions: The WHtR might be a powerful index of the severity of pediatric NAFLD.",

keywords = "Childhood obesity, cutoff value, nonalcoholic fatty liver disease, waist-to-height ratio, waist-to-hip ratio",

author = "Lin, {Ming Shyan} and Lin, {Tsai Hui} and Guo, {Su Er} and Tsai, {Ming Horng} and Chiang, {Ming Shin} and Huang, {Tung Jung} and Chen, {Mei Yen}",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

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doi = "10.1186/s12889-017-4868-5",

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TY - JOUR

T1 - Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents

T2 - A secondary data analysis

AU - Lin, Ming Shyan

AU - Lin, Tsai Hui

AU - Guo, Su Er

AU - Tsai, Ming Horng

AU - Chiang, Ming Shin

AU - Huang, Tung Jung

AU - Chen, Mei Yen

PY - 2017/10/30

Y1 - 2017/10/30

N2 - Background: Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents. Methods: This community-based, cross-sectional study ran from December 2012 to September 2013 in southwestern Taiwan. Children <10 and >19 years old, with detected hepatic diseases, or who drank alcohol were excluded. The diagnosis of NAFLD was based on ultrasound: age, sex, anthropometric measurements, and laboratory data were evaluated for associated risks by using logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine cutoff values. Results: We enrolled one thousand, two hundred and ten children (594 males; 616 females; mean age: 15.5 ± 2.8 years). Age, anthropometric measurements, and laboratory data were significantly higher in children with NAFLD. The association between NAFLD and the waist-to-height ratio (WHtR) was significant (adjusted odds ratio: 2.6; 95% confidence interval: 1.909-3.549; P < 0.001). It indicated highly suspicion of NAFLD (sensitivity: 70.1%; specificity 76.9%) when the WHtR for children and adolescents is above the cutoff value of 0.469. Conclusions: The WHtR might be a powerful index of the severity of pediatric NAFLD.

AB - Background: Nonalcoholic fatty liver disease (NAFLD) is a global problem and pediatric obesity has risen dramatically. Early NAFLD might progress to nonalcoholic steatohepatitis (NASH) or liver cirrhosis and significantly increase liver disease-related mortality. We looked for NAFLD predictors in children and adolescents. Methods: This community-based, cross-sectional study ran from December 2012 to September 2013 in southwestern Taiwan. Children <10 and >19 years old, with detected hepatic diseases, or who drank alcohol were excluded. The diagnosis of NAFLD was based on ultrasound: age, sex, anthropometric measurements, and laboratory data were evaluated for associated risks by using logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine cutoff values. Results: We enrolled one thousand, two hundred and ten children (594 males; 616 females; mean age: 15.5 ± 2.8 years). Age, anthropometric measurements, and laboratory data were significantly higher in children with NAFLD. The association between NAFLD and the waist-to-height ratio (WHtR) was significant (adjusted odds ratio: 2.6; 95% confidence interval: 1.909-3.549; P < 0.001). It indicated highly suspicion of NAFLD (sensitivity: 70.1%; specificity 76.9%) when the WHtR for children and adolescents is above the cutoff value of 0.469. Conclusions: The WHtR might be a powerful index of the severity of pediatric NAFLD.

KW - Childhood obesity

KW - cutoff value

KW - nonalcoholic fatty liver disease

KW - waist-to-height ratio

KW - waist-to-hip ratio

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DO - 10.1186/s12889-017-4868-5

M3 - 文章

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AN - SCOPUS:85032588876

SN - 1471-2458

VL - 17

JO - BMC Public Health

JF - BMC Public Health

IS - 1

M1 - 851

ER -

Waist-to-height ratio is a useful index for nonalcoholic fatty liver disease in children and adolescents: A secondary data analysis

Abstract

Bibliographical note

Keywords

UN SDGs

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