TY - JOUR
T1 - Whole-body diffusion-weighted MR imaging of iron deposits in hodgkin, follicular, and diffuse large b-cell lymphoma
AU - Cottereau, Anne Ségolène
AU - Mulé, Sébastien
AU - Lin, Chieh
AU - Belhadj, Karim
AU - Vignaud, Alexandre
AU - Copie-Bergman, Christiane
AU - Boyez, Alice
AU - Zerbib, Pierre
AU - Tacher, Vania
AU - Scherman, Elodie
AU - Haioun, Corinne
AU - Luciani, Alain
AU - Itti, Emmanuel
AU - Rahmouni, Alain
PY - 2018/2
Y1 - 2018/2
N2 - Purpose: To analyze the frequency and distribution of low-signalintensity regions (LSIRs) in lymphoma lesions and to compare these to fluorodeoxyglucose (FDG) uptake and biologic markers of inflammation. Materials and Methods: The authors analyzed 61 untreated patients with a bulky lymphoma (at least one tumor mass 7 cm in diameter). When a LSIR within tumor lesions was detected on diffusion- weighted images obtained with a b value of 50 sec/ mm2, a T2-weighted gradient-echo (GRE) sequence was performed and calcifications were searched for with computed tomography (CT). In two patients, Perls staining was performed on tissue samples from the LSIR. LSIRs were compared with biologic inflammatory parameters and baseline FDG positon emission tomography (PET)/ CT parameters (maximum standardized uptake value [SUV max], total metabolic tumor volume [TMTV]). Results: LSIRs were detected in 22 patients and corresponded to signal void on GRE images; one LSIR was due to calcifications, and three LSIRS were due to a recent biopsy. In 18 patients, LSIRs appeared to be related to focal iron deposits; this was proven with Perls staining in two patients. The LSIRs presumed to be due to iron deposits were found mostly in patients with aggressive lymphoma (nine of 26 patients with Hodgkin lymphoma and eight of 20 patients with diffuse large B-cell lymphoma vs one of 15 patients with follicular lymphoma; P = .047) and with advanced stage disease (15 of 18 patients). LSIRS were observed in spleen (n = 14), liver (n = 3), and nodal (n = 8) lesions and corresponded to foci FDG uptake, with mean SUVmax of 9.8, 6.7, and 16.2, respectively. These patients had significantly higher serum levels of C-reactive protein, a1-globulin, and a2-globulin and more frequently had microcytic anemia than those without such deposits (P = .0072, P = .003, P = .0068, and P , .0001, respectively). They also had a significantly higher TMTV (P = .0055) and higher levels of spleen involvement (P , .0001). Conclusion: LSIRs due to focal iron deposits are detected in lymphoma lesions and are associated with a more pronounced biologic inflammatory syndrome.
AB - Purpose: To analyze the frequency and distribution of low-signalintensity regions (LSIRs) in lymphoma lesions and to compare these to fluorodeoxyglucose (FDG) uptake and biologic markers of inflammation. Materials and Methods: The authors analyzed 61 untreated patients with a bulky lymphoma (at least one tumor mass 7 cm in diameter). When a LSIR within tumor lesions was detected on diffusion- weighted images obtained with a b value of 50 sec/ mm2, a T2-weighted gradient-echo (GRE) sequence was performed and calcifications were searched for with computed tomography (CT). In two patients, Perls staining was performed on tissue samples from the LSIR. LSIRs were compared with biologic inflammatory parameters and baseline FDG positon emission tomography (PET)/ CT parameters (maximum standardized uptake value [SUV max], total metabolic tumor volume [TMTV]). Results: LSIRs were detected in 22 patients and corresponded to signal void on GRE images; one LSIR was due to calcifications, and three LSIRS were due to a recent biopsy. In 18 patients, LSIRs appeared to be related to focal iron deposits; this was proven with Perls staining in two patients. The LSIRs presumed to be due to iron deposits were found mostly in patients with aggressive lymphoma (nine of 26 patients with Hodgkin lymphoma and eight of 20 patients with diffuse large B-cell lymphoma vs one of 15 patients with follicular lymphoma; P = .047) and with advanced stage disease (15 of 18 patients). LSIRS were observed in spleen (n = 14), liver (n = 3), and nodal (n = 8) lesions and corresponded to foci FDG uptake, with mean SUVmax of 9.8, 6.7, and 16.2, respectively. These patients had significantly higher serum levels of C-reactive protein, a1-globulin, and a2-globulin and more frequently had microcytic anemia than those without such deposits (P = .0072, P = .003, P = .0068, and P , .0001, respectively). They also had a significantly higher TMTV (P = .0055) and higher levels of spleen involvement (P , .0001). Conclusion: LSIRs due to focal iron deposits are detected in lymphoma lesions and are associated with a more pronounced biologic inflammatory syndrome.
UR - http://www.scopus.com/inward/record.url?scp=85041462033&partnerID=8YFLogxK
U2 - 10.1148/radiol.2017170599
DO - 10.1148/radiol.2017170599
M3 - 文章
C2 - 28985135
AN - SCOPUS:85041462033
SN - 0033-8419
VL - 286
SP - 560
EP - 567
JO - Radiology
JF - Radiology
IS - 2
ER -