Wilson's disease: Resolution of MRI lesions following long-term oral zinc therapy

C. C. Huang*, N. S. Chu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

37 Scopus citations

Abstract

A 28-year-old man with Wilson's disease developed neurological deterioration after a low-dose of d-penicillamine treatment for 2 weeks. He showed an akinetic rigid syndrome with generalized dystonia. Brain magnetic resonance images (MRI) on T2 and proton weighted images showed an increased signal intensity over the thalamus, basal ganglia and brainstem, especially the midbrain and pens. After treatment had been changed to zinc sulphate, the akinetic-rigid syndrome and dystonia were improved slowly in the following 4 years. Serial MRI studies showed a gradual resolution of the lesions. His current neurological status was almost normal except for dysarthria and mild intention tremor.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalActa Neurologica Scandinavica
Volume93
Issue number2-3
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Akinetic-rigid syndrome
  • MRI
  • Wilson's disease
  • Zinc sulphate
  • d-penicillamine

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