Withanolides and 26-hydroxylated derivatives with anti-inflammatory property from solanum capsicoide

You Cheng Lin; Chih Hua Chao; Atallah F. Ahmed; Yang Yih Chen; Tsong Long Hwang; Ho Yih Liu; Jyh Horng Sheu

doi:10.1246/bcsj.20180225

Withanolides and 26-hydroxylated derivatives with anti-inflammatory property from solanum capsicoide

You Cheng Lin
, Chih Hua Chao
, Atallah F. Ahmed
, Yang Yih Chen
, Tsong Long Hwang
, Ho Yih Liu
, Jyh Horng Sheu

School of Traditional Chinese Medicine

National Sun Yat-sen University
China Medical University Taichung
King Saud University
Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

A phytochemical investigation of the leaves of Solanum capsicoides resulted in the isolation and characterization of five new withanolide-type steroids, capsisteroids G-K (1-5), along with three known analogues (6-8). Their structures were identified by interpretation of the NMR and HRESIMS data as well as by spectral data comparison with known analogues. The isolated steroids were found to be not cytotoxic against a limited panel of cancer cell lines. The ability of the isolated steroids to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils was also evaluated and displayed variable activities.

Original language	English
Pages (from-to)	336-343
Number of pages	8
Journal	Bulletin of the Chemical Society of Japan
Volume	92
Issue number	2
DOIs	https://doi.org/10.1246/bcsj.20180225
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 The Chemical Society of Japan.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

26-Hydroxylated
Capsisteroid
Solanum capsicoides

Access to Document

10.1246/bcsj.20180225

Cite this

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title = "Withanolides and 26-hydroxylated derivatives with anti-inflammatory property from solanum capsicoide",

abstract = "A phytochemical investigation of the leaves of Solanum capsicoides resulted in the isolation and characterization of five new withanolide-type steroids, capsisteroids G-K (1-5), along with three known analogues (6-8). Their structures were identified by interpretation of the NMR and HRESIMS data as well as by spectral data comparison with known analogues. The isolated steroids were found to be not cytotoxic against a limited panel of cancer cell lines. The ability of the isolated steroids to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils was also evaluated and displayed variable activities.",

keywords = "26-Hydroxylated, Capsisteroid, Solanum capsicoides",

author = "Lin, \{You Cheng\} and Chao, \{Chih Hua\} and Ahmed, \{Atallah F.\} and Chen, \{Yang Yih\} and Hwang, \{Tsong Long\} and Liu, \{Ho Yih\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Chemical Society of Japan.",

year = "2019",

doi = "10.1246/bcsj.20180225",

language = "英语",

volume = "92",

pages = "336--343",

journal = "Bulletin of the Chemical Society of Japan",

issn = "0009-2673",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Withanolides and 26-hydroxylated derivatives with anti-inflammatory property from solanum capsicoide

AU - Lin, You Cheng

AU - Chao, Chih Hua

AU - Ahmed, Atallah F.

AU - Chen, Yang Yih

AU - Hwang, Tsong Long

AU - Liu, Ho Yih

AU - Sheu, Jyh Horng

PY - 2019

Y1 - 2019

N2 - A phytochemical investigation of the leaves of Solanum capsicoides resulted in the isolation and characterization of five new withanolide-type steroids, capsisteroids G-K (1-5), along with three known analogues (6-8). Their structures were identified by interpretation of the NMR and HRESIMS data as well as by spectral data comparison with known analogues. The isolated steroids were found to be not cytotoxic against a limited panel of cancer cell lines. The ability of the isolated steroids to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils was also evaluated and displayed variable activities.

AB - A phytochemical investigation of the leaves of Solanum capsicoides resulted in the isolation and characterization of five new withanolide-type steroids, capsisteroids G-K (1-5), along with three known analogues (6-8). Their structures were identified by interpretation of the NMR and HRESIMS data as well as by spectral data comparison with known analogues. The isolated steroids were found to be not cytotoxic against a limited panel of cancer cell lines. The ability of the isolated steroids to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils was also evaluated and displayed variable activities.

KW - 26-Hydroxylated

KW - Capsisteroid

KW - Solanum capsicoides

UR - https://www.scopus.com/pages/publications/85061819193

U2 - 10.1246/bcsj.20180225

DO - 10.1246/bcsj.20180225

M3 - 文章

AN - SCOPUS:85061819193

SN - 0009-2673

VL - 92

SP - 336

EP - 343

JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

IS - 2

ER -

Withanolides and 26-hydroxylated derivatives with anti-inflammatory property from solanum capsicoide

Abstract

Bibliographical note

UN SDGs

Keywords

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