TY - JOUR
T1 - Worldwide time trends in prevalence of symptoms of rhinoconjunctivitis in children
T2 - Global Asthma Network Phase I
AU - the Global Asthma Network Phase I Study Group
AU - Strachan, David P.
AU - Rutter, Charlotte E.
AU - Asher, Monica Innes
AU - Bissell, Karen
AU - Chiang, Chen Yuan
AU - El Sony, Asma
AU - Ellwood, Eamon
AU - Ellwood, Philippa
AU - García-Marcos, Luis
AU - Marks, Guy B.
AU - Morales, Eva
AU - Mortimer, Kevin
AU - Pearce, Neil
AU - Pérez-Fernández, Virginia
AU - Robertson, Steven
AU - Silverwood, Richard J.
AU - Navarrete-Rodriguez, E. M.
AU - López-Silvarrey Varela, A.
AU - Asher, M. I.
AU - Bissell, K.
AU - El Sony, A.
AU - Mortimer, K.
AU - Strachan, D. P.
AU - Asher, M. I.
AU - Perez-Fernández, V.
AU - Morales, E.
AU - Martinez-Torres, A.
AU - Strachan, D. P.
AU - Robertson, S.
AU - Rutter, C. E.
AU - Mallol, J.
AU - Soto-Martinez, M.
AU - Singh, M.
AU - Singh, V.
AU - Awasthi, S.
AU - Kabra, S. K.
AU - Salvi, S.
AU - Mérida-Palacio, J. V.
AU - González-Díaz, S. N.
AU - Eleuterio González, José
AU - Sánchez, J. F.
AU - Falade, A.
AU - Zar, H. J.
AU - López-Silvarrey Varela, A.
AU - González Díaz, C.
AU - Nour, M.
AU - Dib, G.
AU - Huang, J. L.
AU - Chinratanapisit, S.
AU - Soto-Quirós, M. E.
N1 - Publisher Copyright:
© 2021 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Background: The Global Asthma Network (GAN), by using the International Study of Asthma and Allergies in Childhood (ISAAC) methodology, has updated trends in prevalence of symptoms of childhood allergic diseases, including non-infective rhinitis and conjunctivitis (‘rhinoconjunctivitis’), which is reported here. Methods: Prevalence and severity of rhinoconjunctivitis were assessed by questionnaire among schoolchildren in GAN Phase I and ISAAC Phase I and III surveys 15–23 years apart. Absolute rates of change in prevalence were estimated for each centre and modelled by multi-level linear regression to compare trends by age group, time period and per capita national income. Results: Twenty-seven GAN centres in 14 countries surveyed 74,361 13- to 14-year-olds (‘adolescents’) and 45,434 6- to 7-year-olds (‘children’), with average response proportions of 90% and 79%, respectively. Many centres showed highly significant (p <.001) changes in prevalence of rhinoconjunctivitis in the past year (‘current rhinoconjunctivitis’) compared with ISAAC. The direction and magnitude of centre-level trends varied significantly (p <.001) both within and between countries. Overall, current rhinoconjunctivitis prevalence decreased slightly from ISAAC Phase III to GAN: −1.32% per 10 years, 95% CI [−2.93%, +0.30%] among adolescents; and −0.44% [−1.29%, +0.42%] among children. Together, these differed significantly (p <.001) from the upward trend within ISAAC. Among adolescents, centre-level trends in current rhinoconjunctivitis were highly correlated with those for eczema symptoms (rho = 0.72, p <.0001) but not with centre-level trends in asthma symptoms (rho = 0.15, p =.48). Among children, these correlations were positive but not significant. Conclusion: Symptoms of non-infective rhinoconjunctivitis among schoolchildren may no longer be on the increase globally, although trends vary substantially within and between countries.
AB - Background: The Global Asthma Network (GAN), by using the International Study of Asthma and Allergies in Childhood (ISAAC) methodology, has updated trends in prevalence of symptoms of childhood allergic diseases, including non-infective rhinitis and conjunctivitis (‘rhinoconjunctivitis’), which is reported here. Methods: Prevalence and severity of rhinoconjunctivitis were assessed by questionnaire among schoolchildren in GAN Phase I and ISAAC Phase I and III surveys 15–23 years apart. Absolute rates of change in prevalence were estimated for each centre and modelled by multi-level linear regression to compare trends by age group, time period and per capita national income. Results: Twenty-seven GAN centres in 14 countries surveyed 74,361 13- to 14-year-olds (‘adolescents’) and 45,434 6- to 7-year-olds (‘children’), with average response proportions of 90% and 79%, respectively. Many centres showed highly significant (p <.001) changes in prevalence of rhinoconjunctivitis in the past year (‘current rhinoconjunctivitis’) compared with ISAAC. The direction and magnitude of centre-level trends varied significantly (p <.001) both within and between countries. Overall, current rhinoconjunctivitis prevalence decreased slightly from ISAAC Phase III to GAN: −1.32% per 10 years, 95% CI [−2.93%, +0.30%] among adolescents; and −0.44% [−1.29%, +0.42%] among children. Together, these differed significantly (p <.001) from the upward trend within ISAAC. Among adolescents, centre-level trends in current rhinoconjunctivitis were highly correlated with those for eczema symptoms (rho = 0.72, p <.0001) but not with centre-level trends in asthma symptoms (rho = 0.15, p =.48). Among children, these correlations were positive but not significant. Conclusion: Symptoms of non-infective rhinoconjunctivitis among schoolchildren may no longer be on the increase globally, although trends vary substantially within and between countries.
KW - allergic disease
KW - conjunctivitis
KW - prevalence
KW - rhinitis
KW - time trend
UR - http://www.scopus.com/inward/record.url?scp=85123228420&partnerID=8YFLogxK
U2 - 10.1111/pai.13656
DO - 10.1111/pai.13656
M3 - 文章
C2 - 34453861
AN - SCOPUS:85123228420
SN - 0905-6157
VL - 33
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 1
M1 - e13656
ER -