WWP1 gene is a potential molecular target of human oral cancer

Ju Hwa Lin; Shu Chen Hsieh; Jia Ni Chen; Ming Hsui Tsai; Chia Che Chang

doi:10.1016/j.oooo.2013.05.006

WWP1 gene is a potential molecular target of human oral cancer

Ju Hwa Lin^*, Shu Chen Hsieh, Jia Ni Chen, Ming Hsui Tsai, Chia Che Chang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

Objective: This study investigates the oncogenic role of WWP1, an ubiquitin ligase linked to tumor promotion, in oral cancer. Study design: An array-based comparative genomic hybridization was used to detect chromosomal changes in 10 oral cancer specimens. An additional 59 specimens and 6 cultured oral cancer cells were further examined to evaluate changes in the DNA copy number and messenger RNA (mRNA) and protein expression of WWP1. Results: The copy number of the WWP1 gene and its mRNA levels were significantly increased in the oral cancer specimens. An elevated WWP1 gene expression was observed in 6 cultured oral cancer cell lines. Knockdown of the endogenous WWP1 using small hairpin RNA further showed that deficiency of WWP1 suppressed cell growth and caused apoptosis in oral cancer cells. Conclusion: Our results reveal that WWP1 might play an oncogenic role in oral cancer cells.

Original language	English
Pages (from-to)	221-231
Number of pages	11
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/j.oooo.2013.05.006
State	Published - 08 2013
Externally published	Yes

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title = "WWP1 gene is a potential molecular target of human oral cancer",

abstract = "Objective: This study investigates the oncogenic role of WWP1, an ubiquitin ligase linked to tumor promotion, in oral cancer. Study design: An array-based comparative genomic hybridization was used to detect chromosomal changes in 10 oral cancer specimens. An additional 59 specimens and 6 cultured oral cancer cells were further examined to evaluate changes in the DNA copy number and messenger RNA (mRNA) and protein expression of WWP1. Results: The copy number of the WWP1 gene and its mRNA levels were significantly increased in the oral cancer specimens. An elevated WWP1 gene expression was observed in 6 cultured oral cancer cell lines. Knockdown of the endogenous WWP1 using small hairpin RNA further showed that deficiency of WWP1 suppressed cell growth and caused apoptosis in oral cancer cells. Conclusion: Our results reveal that WWP1 might play an oncogenic role in oral cancer cells.",

author = "Lin, {Ju Hwa} and Hsieh, {Shu Chen} and Chen, {Jia Ni} and Tsai, {Ming Hsui} and Chang, {Chia Che}",

year = "2013",

month = aug,

doi = "10.1016/j.oooo.2013.05.006",

language = "英语",

volume = "116",

pages = "221--231",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

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publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - WWP1 gene is a potential molecular target of human oral cancer

AU - Lin, Ju Hwa

AU - Hsieh, Shu Chen

AU - Chen, Jia Ni

AU - Tsai, Ming Hsui

AU - Chang, Chia Che

PY - 2013/8

Y1 - 2013/8

N2 - Objective: This study investigates the oncogenic role of WWP1, an ubiquitin ligase linked to tumor promotion, in oral cancer. Study design: An array-based comparative genomic hybridization was used to detect chromosomal changes in 10 oral cancer specimens. An additional 59 specimens and 6 cultured oral cancer cells were further examined to evaluate changes in the DNA copy number and messenger RNA (mRNA) and protein expression of WWP1. Results: The copy number of the WWP1 gene and its mRNA levels were significantly increased in the oral cancer specimens. An elevated WWP1 gene expression was observed in 6 cultured oral cancer cell lines. Knockdown of the endogenous WWP1 using small hairpin RNA further showed that deficiency of WWP1 suppressed cell growth and caused apoptosis in oral cancer cells. Conclusion: Our results reveal that WWP1 might play an oncogenic role in oral cancer cells.

AB - Objective: This study investigates the oncogenic role of WWP1, an ubiquitin ligase linked to tumor promotion, in oral cancer. Study design: An array-based comparative genomic hybridization was used to detect chromosomal changes in 10 oral cancer specimens. An additional 59 specimens and 6 cultured oral cancer cells were further examined to evaluate changes in the DNA copy number and messenger RNA (mRNA) and protein expression of WWP1. Results: The copy number of the WWP1 gene and its mRNA levels were significantly increased in the oral cancer specimens. An elevated WWP1 gene expression was observed in 6 cultured oral cancer cell lines. Knockdown of the endogenous WWP1 using small hairpin RNA further showed that deficiency of WWP1 suppressed cell growth and caused apoptosis in oral cancer cells. Conclusion: Our results reveal that WWP1 might play an oncogenic role in oral cancer cells.

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DO - 10.1016/j.oooo.2013.05.006

M3 - 文章

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AN - SCOPUS:84880191959

SN - 2212-4403

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JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

IS - 2

ER -

WWP1 gene is a potential molecular target of human oral cancer

Abstract

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