(-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils, and further constituents of the seeds of Xanthium strumarium

Chia Lin Lee, Po Ching Huang, Pei Wen Hsieh, Tsong Long Hwang, Yu Yi Hou, Fang Rong Chang*, Yang Chang Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

26 Scopus citations

Abstract

The dried seeds of Xanthium strumarium (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde (2) and (-)-xanthienopyran (7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl-L-methionyl-L-leucyl-L-phenylalanine, with an IC50 value of 1.72 μg/mL.

Original languageEnglish
Pages (from-to)1276-1279
Number of pages4
JournalPlanta Medica
Volume74
Issue number10
DOIs
StatePublished - 08 2008

Keywords

  • Asteraceae
  • Cang-Er Zi
  • Neutrophils
  • Superoxide anion generation inhibitor
  • Xanthium strumarium

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