藥理學科

2024

ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor MTX-211 in Cancer Cells

Wu, C. P., Hung, C. Y., Murakami, M., Wu, Y. S., Chu, Y. H., Huang, Y. H., Yu, J. S. & Ambudkar, S. V., 05 2024, 於: International Journal of Molecular Sciences. 25, 10, 5160.

研究成果: 期刊稿件 › 文章 › 同行評審

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Carbonization of quercetin into nanogels: a leap in anticoagulant development

Chu, H. W., Chen, W. J., Liu, K. H., Mao, J. Y., Harroun, S. G., Unnikrishnan, B., Lin, H. J., Ma, Y. H., Chang, H. T. & Huang, C. C., 05 06 2024, 於: Journal of Materials Chemistry B. 12, 22, p. 5391-5404 14 p.

研究成果: 期刊稿件 › 文章 › 同行評審

Epidermal Growth Factor Receptor Inhibitor Mobocertinib Resensitizes Multidrug-Resistant Cancer Cells by Attenuating the Human ATP-Binding Cassette Subfamily B Member 1 and Subfamily G Member 2

Li, Y. C., Hsiao, S. H., Murakami, M., Huang, Y. H., Chang, Y. T., Hung, T. H., Wu, Y. S., Ambudkar, S. V. & Wu, C. P., 12 01 2024, 於: ACS Pharmacology and Translational Science. 7, 1, p. 161-175 15 p.

研究成果: 期刊稿件 › 文章 › 同行評審

Translational Assessment of Magnetic Nanotherapeutics for Target Thrombolysis

Ma, Y.-H., 2024.

研究成果: 會議稿件的類型 › 會議論文

出席「14th International Conference on the Scientific and Clinical Applications of Magnetic Carriers」報告

Ma, Y.-H., 2024.

研究成果: 會議稿件的類型 › 出席國際會議報告

出席「第144屆日本藥學會年會」報告

Wu, C.-P., 2024.

研究成果: 會議稿件的類型 › 出席國際會議報告

2023

ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

Wu, C. P., Hung, C. Y., Hsieh, Y.-J., Murakami, M., Huang, Y. H., Su, T. Y., Hung, T.-H., Yu, J. S., Wu, Y. S. & Ambudkar, S. V., 30 03 2023, 於: Cells. 12, 7, 1056.

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4 引文斯高帕斯（Scopus）

A novel quinazolinone HoLu-4 exhibits p53-dependent anticancer activity against colorectal cancer

Lai, K.-C., Hour, M.-J., Lin, Y.-J. & Yen, C.-Y., 2023.

研究成果: 會議稿件的類型 › 會議論文

Aptamer-Guided Targeting of Tissue Plasminogen Activator-Loaded Carbon Nanovesicles to Thrombus for Thrombolytic Therapy

Ma, Y.-H., Huang, C.-C. & Wu, R.-S., 2023.

研究成果: 會議稿件的類型 › 會議論文

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Taiwan Severe Cutaneous Adverse Reaction Consortium, 2023, 於: Frontiers in Pharmacology. 14, p. 1183491 1183491.

研究成果: 期刊稿件 › 短篇評述 › 同行評審

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4 引文斯高帕斯（Scopus）

Expression of HLA class II is correlated with lymph node metastasis in oral cancer

Lai, K.-C., Chang, P.M.-H., Chen, C.-W., Chu, C.-H., Liao, Y.-C. & Wang, C.-W., 2023.

研究成果: 會議稿件的類型 › 會議論文

Furmonertinib, a Third-Generation EGFR Tyrosine Kinase Inhibitor, Overcomes Multidrug Resistance through Inhibiting ABCB1 and ABCG2 in Cancer Cells

Wu, C. P., Li, Y. C., Murakami, M., Hsiao, S. H., Lee, Y. C., Huang, Y. H., Chang, Y. T., Hung, T. H., Wu, Y. S. & Ambudkar, S. V., 12 09 2023, 於: International Journal of Molecular Sciences. 24, 18, 13972.

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3 引文斯高帕斯（Scopus）

IFIT2 Depletion Promotes Cancer Stem Cell-like Phenotypes in Oral Cancer

Lai, K. C., Regmi, P., Liu, C. J., Lo, J. F. & Lee, T. C., 14 03 2023, 於: Biomedicines. 11, 3, 896.

研究成果: 期刊稿件 › 文章 › 同行評審

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2 引文斯高帕斯（Scopus）

Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport

Wu, C. P., Murakami, M., Li, Y. C., Huang, Y. H., Chang, Y. T., Hung, T.-H., Wu, Y. S. & Ambudkar, S. V., 11 2023, 於: Pharmaceuticals. 16, 11, 1595.

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1 引文斯高帕斯（Scopus）

Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2

Wu, C. P., Hsiao, S. H. & Wu, Y. S., 11 2023, 於: Drug Resistance Updates. 71, 101011.

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9 引文斯高帕斯（Scopus）

Tannic Acid-Coating Enhances Magnetic Nanoparticle Uptake by Human Glioblastoma Cells

Ma, Y.-H., Daniel, H. & Lin, M.-L., 2023.

研究成果: 會議稿件的類型 › 會議論文

The cellular responses of corneal fibroblasts to cyclic stretching loads

Tan, H. Y., Wu, Y. F., Wang, C. Y., Lin, S. J., Ma, Y. H. & Young, T. H., 12 2023, 於: Experimental Eye Research. 237, 109696.

研究成果: 期刊稿件 › 文章 › 同行評審

出席The 82nd Annual Meeting of The Japanese Cancer Association報告

Wu, C.-P., 2023.

研究成果: 會議稿件的類型 › 出席國際會議報告

探討Epertinib及Vodobatinib在過度表達ABCB1與ABCG2之多重抗藥性癌細胞中的化學增敏作用

林秉寰, 2023, 142 p.

研究成果: 論文類型 › 碩士論文

探討Furmonertinib以及Edicotinib對於過度表現ABCB1或ABCG2之多重抗藥性癌細胞的化療藥物敏感性之影響

李昀倢, 2023, 115 p.

研究成果: 論文類型 › 碩士論文

新型喹唑啉酮HoLu-4在大腸直腸癌中表現p53依賴的抗癌活性

顏君伃, 2023, 78 p.

研究成果: 論文類型 › 碩士論文

2022

A Novel Hybrid Bifunctional Alkylating Agent That Potently Suppresses the Growth of mCRC Cells Xenografts and Patient-Derived Organoids

Navakanth Rao, V., Kuo-Chu, L., Chin-Huang, L., Joanne Jeou-Yuan, C., Tsann-Long, S. & Te-Chang, L., 10 2022, 於: European Journal of Cancer. 174, p. S114

研究成果: 期刊稿件 › 文章 › 同行評審

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A novel hybrid with anti-angiogenic and DNA crosslinking activities potently suppresses the growth of colorectal cancer cells and patient-derived organoids in mice.

Rao, V. N., Lai, K.-C., Liu, C.-H., Yang, S.-H., Chang, J.-Y., Su, T.-L. & Lee, T.-C., 2022, 於: Cancer Research. 82, 23

研究成果: 期刊稿件 › 文章 › 同行評審

Characterization of mesenchymal stem cells with augmented internalization of magnetic nanoparticles: The implication of therapeutic potential

Chien, C. H., Liu, Y. S., Chang, Y. T. & Ma, Y. H., 15 12 2022, 於: Journal of Magnetism and Magnetic Materials. 564, 170060.

研究成果: 期刊稿件 › 文章 › 同行評審

Cyclic Strain Mitigates Nanoparticle Internalization by Vascular Smooth Muscle Cells

Tsai, C. L., Huang, C. Y., Lu, Y. C., Pai, L. M., Horák, D. & Ma, Y. H., 2022, 於: International Journal of Nanomedicine. 17, p. 969-981 13 p.

研究成果: 期刊稿件 › 文章 › 同行評審

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3 引文斯高帕斯（Scopus）

Hydroxygenkwanin Improves the Efficacy of Cytotoxic Drugs in ABCG2-Overexpressing Multidrug-Resistant Cancer Cells

Li, Y. Q., Murakami, M., Huang, Y. H., Hung, T. H., Wang, S. P., Wu, Y. S., Ambudkar, S. V. & Wu, C. P., 11 2022, 於: International Journal of Molecular Sciences. 23, 21, 12763.

研究成果: 期刊稿件 › 文章 › 同行評審

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1 引文斯高帕斯（Scopus）

IFIT2-depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice

Lai, K. C., Hong, Z. X., Hsieh, J. G., Lee, H. J., Yang, M. H., Hsieh, C. H., Yang, C. H. & Chen, Y. R., 04 2022, 於: Journal of Cachexia, Sarcopenia and Muscle. 13, 2, p. 1314-1328 15 p.

研究成果: 期刊稿件 › 文章 › 同行評審

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6 引文斯高帕斯（Scopus）

Laminin Receptor-Mediated Nanoparticle Uptake by Tumor Cells: Interplay of Epigallocatechin Gallate and Magnetic Force at Nano–Bio Interface

Hsu, S. C., Wu, N. P., Lu, Y. C. & Ma, Y. H., 08 2022, 於: Pharmaceutics. 14, 8, 1523.

研究成果: 期刊稿件 › 文章 › 同行評審

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5 引文斯高帕斯（Scopus）

P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhiitor Ensartinib in Cancer Cells

Wu, C. P., Hung, C. Y., Murakami, M., Wu, Y. S., Lin, C. L., Huang, Y. H., Hung, T. H., Yu, J. S. & Ambudkar, S. V., 01 05 2022, 於: Cancers. 14, 9, 2341.

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8 引文斯高帕斯（Scopus）

Tannic Acid Coating Augments Glioblastoma Cellular Uptake of Magnetic Nanoparticles with Antioxidant Effects

Świętek, M., Ma, Y. H., Wu, N. P., Paruzel, A., Tokarz, W. & Horák, D., 01 04 2022, 於: Nanomaterials. 12, 8, 1310.

研究成果: 期刊稿件 › 文章 › 同行評審

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10 引文斯高帕斯（Scopus）

The multi-targeted tyrosine kinase inhibitor SKLB610 resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs

Wu, C. P., Murakami, M., Wu, Y. S., Lin, C. L., Li, Y. Q., Huang, Y. H., Hung, T. H. & Ambudkar, S. V., 05 2022, 於: Biomedicine and Pharmacotherapy. 149, 112922.

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4 引文斯高帕斯（Scopus）

The WD repeat-containing protein 5 (WDR5) antagonist WDR5-0103 restores the efficacy of cytotoxic drugs in multidrug-resistant cancer cells overexpressing ABCB1 or ABCG2

Wu, C. P., Hsieh, Y.-J., Tseng, H. Y., Huang, Y. H., Li, Y. Q., Hung, T.-H., Wang, S. P. & Wu, Y. S., 10 2022, 於: Biomedicine and Pharmacotherapy. 154, 113663.

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5 引文斯高帕斯（Scopus）

出席「6th Cancer World Congress」會議報告

Jou, M.-J., 2022.

研究成果: 會議稿件的類型 › 出席國際會議報告

研究WDR5抑制劑WDR5-0103以及酪胺酸激酶抑制劑Lazertinib對於過度表現ABCB1或ABCG2之多重抗藥性癌細胞的增敏作用

曾涵郁, 2022, 120 p.

研究成果: 論文類型 › 碩士論文

標靶第十三凝血因子適體之優化與驗證

曾郁軒, 2022, 78 p.

研究成果: 論文類型 › 碩士論文

2021

A dual functional agent inhibits the angiogenesis and DNA synthesis resulting in the growth suppression of consensus molecular subtypes 1 and 4 in colorectal cancer xenografts.

Rao, V. N., Kuppuswamy, R., Lai, K.-C., Su, T.-L. & Lee, T.-C., 2021, 於: Cancer Research. 81, 13

研究成果: 期刊稿件 › 文章 › 同行評審

Antitumor effects of the novel quinazolinone holu-12: Induction of mitotic arrest and apoptosis in human oral squamous cell carcinoma CAL27 cells

LAI, K. C., CHIA, Y. T., YIH, L. H., LU, Y. L., CHANG, S. T., HONG, Z. X., CHEN, T. L. & HOUR, M. J., 01 2021, 於: Anticancer Research. 41, 1, p. 259-268 10 p.

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4 引文斯高帕斯（Scopus）

Association of PEGylated Iron Oxide Nanoparticle-Induced Complement Activation and Acute Hypersensitivity Reactions: A Proteomic Study of Protein Corona

貢獻的翻譯標題: 聚乙二醇修飾之氧化鐵奈米粒子所引發之補體活化與急性超敏反應之關聯性:蛋白冠之蛋白質體學研究程筠, 2021, 141 p.

研究成果: 論文類型 › 碩士論文

Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents

Wu, C. P., Murakami, M., Wu, Y. S., Chi, Y. C., Hsiao, S. H., Huang, Y. H., Hung, T. H. & Ambudkar, S. V., 19 07 2021, 於: Frontiers in Cell and Developmental Biology. 9, 699571.

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6 引文斯高帕斯（Scopus）

Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants

Hung, T. H., Wu, C. P. & Chen, S. F., 06 12 2021, 於: Frontiers in Medicine. 8, 788969.

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10 引文斯高帕斯（Scopus）

Overexpression of human abcb1 and abcg2 reduces the susceptibility of cancer cells to the histone deacetylase 6-specific inhibitor citarinostat

Wu, C. P., Hung, C. Y., Lusvarghi, S., Chang, Y. F., Hsiao, S. H., Huang, Y. H., Hung, T. H., Yu, J. S. & Ambudkar, S. V., 01 03 2021, 於: International Journal of Molecular Sciences. 22, 5, p. 1-14 14 p., 2592.

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10 引文斯高帕斯（Scopus）

Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs

Wu, C. P., Li, Y. Q., Hung, T. H., Chang, Y. T., Huang, Y. H. & Wu, Y. S., 24 09 2021, 於: Journal of Natural Products. 84, 9, p. 2544-2553 10 p.

研究成果: 期刊稿件 › 文獻綜述 › 同行評審

8 引文斯高帕斯（Scopus）

The second‐generation pim kinase inhibitor tp‐3654 resensitizes abcg2‐overexpressing multidrug‐resistant cancer cells to cytotoxic anticancer drugs

Wu, C. P., Li, Y. Q., Chi, Y. C., Huang, Y. H., Hung, T. H. & Wu, Y. S., 01 09 2021, 於: International Journal of Molecular Sciences. 22, 17, 9440.

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4 引文斯高帕斯（Scopus）

The third-generation EGFR inhibitor almonertinib (HS-10296) resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs

Wu, C. P., Hung, T. H., Lusvarghi, S., Chu, Y. H., Hsiao, S. H., Huang, Y. H., Chang, Y. T. & Ambudkar, S. V., 06 2021, 於: Biochemical Pharmacology. 188, 114516.

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28 引文斯高帕斯（Scopus）

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