放射醫學研究中心

2025

Degradation analysis of commercial off-the-shelf (COTS) electronics system under gamma radiation

Cho, I. C., Tan, C. M., Baruah, N. A., Shabir, A., Singh, H. T. T., Chao, T. C. & Chu, C. H., 03 2025, 於: Results in Engineering. 25, 103802.

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Gold Nanoparticle-Enhanced Production of Reactive Oxygen Species for Radiotherapy and Phototherapy

Nguyen, V. K., Tsai, S. W., Cho, I. C., Chao, T. C., Hsiao, I. T., Huang, H. C. & Liaw, J. W., 19 02 2025, 於: Nanomaterials. 15, 4, 317.

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Optimizing minibeam collimator design for enhancing normal tissue sparing in ocular tumour proton therapy

Chan, T. Y., Lin, C. Y., Lee, S. H., Liaw, J. W., Chao, T. C. & Cho, I. C., 07 2025, 於: Radiation Physics and Chemistry. 232, 112674.

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Paper-based molecularly imprinted film designs for sensing human serum albumin

Lin, T. C., Lin, C. Y., Hwang, Y. T. & Tai, D. F., 08 2025, 於: Talanta Open. 11, 100421.

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2024

An investigation into the impact of volumetric rescanning and fractionation treatment on dose homogeneity in liver cancer proton therapy

Lee, P. Y., Huang, B. S., Lee, S. H., Chan, T. Y., Yen, E., Lee, T. F. & Cho, I. C., 19 01 2024, 於: Journal of Radiation Research. 65, 1, p. 100-108 9 p.

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Dysregulation of choline metabolism and therapeutic potential of citicoline in Huntington's disease

Chang, K. H., Cheng, M. L., Tang, H. Y., Lin, C. Y. & Chen, C. M., 11 2024, 於: Aging Cell. 23, 11, p. e14302 e14302.

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Endometrial cancer risk stratification using MRI radiomics: corroborating with choline metabolism

Lin, Y., Wu, R. C., Lin, Y. C., Huang, Y. L., Lin, C. Y., Lo, C. J., Lu, H. Y., Lu, K. Y., Tsai, S. Y., Hsieh, C. Y., Yang, L. Y., Cheng, M. L., Chao, A., Lai, C. H. & Lin, G., 24 08 2024, 於: Cancer Imaging. 24, 1, p. 112 112.

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Hyperpolarized [1-¹³C]-pyruvate MRS evaluates immune potential and predicts response to radiotherapy in cervical cancer

Lin, G., Hsieh, C. Y., Lai, Y. C., Wang, C. C., Lin, Y., Lu, K. Y., Chai, W. Y., Chen, A. P., Yen, T. C., Ng, S. H. & Lai, C. H., 10 04 2024, 於: European Radiology Experimental. 8, 1, p. 46 46.

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2 引文斯高帕斯（Scopus）

Mini-ridge filter designs for conformal FLASH proton therapy

Chan, T. Y., Cho, I. C., Farooq, A., Fan, K. H., Tsai, Y. T., Chao, T. C. & Wang, C. C., 11 2024, 於: Radiation Physics and Chemistry. 224, 112017.

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Neuroprotection effects of kynurenic acid-loaded micelles for the Parkinson’s disease models

Chen, C. M., Huang, C. Y., Lai, C. H., Chen, Y. C., Hwang, Y. T. & Lin, C. Y., 2024, 於: Journal of Liposome Research. 34, 4, p. 593-604 12 p.

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2 引文斯高帕斯（Scopus）

Nucleos(t)ide analogues potentially activate T lymphocytes through inducing interferon expression in hepatic cells and patients with chronic hepatitis B

Ho, A. S., Chang, J., Lee, S. D., Sie, Z. L., Shih, H. F., Yeh, C., Peng, C. L., Dev, K. & Cheng, C. C., 25 10 2024, 於: Scientific Reports. 14, 1, p. 25286 25286.

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Proton FLASH Irradiation Platform for Small Animal Setup at Chang Gung Memorial Hospital

Hsiao, T. Y., Wang, L. K., Chen, T. Y., Yu, C. F., Pan, C. Y., Wang, C. C., Lin, C. Y., Cho, I.-C., Chen, F. H., Niu, H. & Chen, C. H., 01 01 2024, 於: IEEE Transactions on Radiation and Plasma Medical Sciences. 8, 1, p. 88-94 7 p.

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1 引文斯高帕斯（Scopus）

The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers

Ochirbat, S., Kan, T. C., Hsu, C. C., Huang, T. H., Chuang, K. H., Chen, M., Cheng, C. C., Chang, C. C., Rahayu, S. & Chang, J., 11 2024, 於: Angiogenesis. 27, 4, p. 827-843 17 p.

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The Deep Space Radiation Probe: Development of a first lunar science payload for space environment studies and capacity building

Chang, L., Lin, W.-Y., Chou, Y.-H., Lin, J.-S., Lung, C., Chen, I., Hou, K.-J., Gacal, G. F., Chiu, Y.-C., Wang, Y., Chou, H.-H., Chao, C.-K., Liu, J.-Y., Hsiao, T.-Y., IChun, C., Date, T., Urata, M., Taeda, M., Tanaka, K. & Vasovic, N. 及其他1, Keegan, N., 05 2024, 於: Advances in Space Research.

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2 引文斯高帕斯（Scopus）

The development of patient-specific quality assurance (PSQA) for a proton wobbling nozzle using PTSim Monte Carlo code

Oanh, L. D. H., Aso, T., Wang, C. C., Chao, T. C. & Cho, I. C., 10 2024, 於: Radiation Physics and Chemistry. 223, 111953.

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Tumor-intrinsic IFNα and CXCL10 are critical for immunotherapeutic efficacy by recruiting and activating T lymphocytes in tumor microenvironment

Cheng, C. C., Chang, J., Ho, A. S., Sie, Z. L., Peng, C. L., Wang, C., Dev, K. & Chang, C. C., 02 07 2024, 於: Cancer Immunology, Immunotherapy. 73, 9, p. 175 175.

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3 引文斯高帕斯（Scopus）

2023

Biocompatible Cerium Carbonate-Based Nanozymes for Oxidase Activity, Sensing, Computed Tomography Contrast, and Delivery of Small Molecules

Thangudu, S., Lee, C. J. & Su, C. H., 28 07 2023, 於: ACS Applied Nano Materials. 6, 14, p. 12922-12932 11 p.

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2 引文斯高帕斯（Scopus）

Comparing Magnetic Resonance Fingerprinting (MRF) and the MAGiC Sequence for Simultaneous T1 and T2 Quantitative Measurements in the Female Pelvis: A Prospective Study

Huang, B. S., Hsieh, C. Y., Chai, W. Y., Lin, Y., Huang, Y. L., Lu, K. Y., Chiang, H. J., Schulte, R. F., Lin, C. Y. E. & Lin, G., 23 06 2023, 於: Diagnostics. 13, 13, 2147.

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2 引文斯高帕斯（Scopus）

Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity

Yang, P. N., Chen, W. L., Lee, J. W., Lin, C. H., Chen, Y. R., Lin, C. Y., Lin, W., Yao, C. F., Wu, Y. R., Chang, K. H., Chen, C. M. & Lee-Chen, G. J., 11 08 2023, 於: Aging. 15, 16, p. 8061-8089 29 p.

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3 引文斯高帕斯（Scopus）

Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive ¹⁸F-FDG PET/CT and Serum ¹H-NMR Analysis: An Orthotopic Murine Model Study

Chung, Y. H., Hung, T. H., Yu, C. F., Tsai, C. K., Weng, C. C., Jhang, F., Chen, F. H. & Lin, G., 09 01 2023, 於: Metabolites. 13, 1, 110.

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3 引文斯高帕斯（Scopus）

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease

Chiu, Y. J., Lin, C. H., Lin, C. Y., Yang, P. N., Lo, Y. S., Chen, Y. C., Chen, C. M., Wu, Y. R., Yao, C. F., Chang, K. H. & Lee-Chen, G. J., 30 01 2023, 於: International Journal of Molecular Sciences. 24, 3, 2642.

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10 引文斯高帕斯（Scopus）

Ligand free FeSn₂ alloy nanoparticles for safe T₂-weighted MR imaging of in vivo lung tumors

Thangudu, S., Lin, W. C., Lee, C. L., Liao, M. C., Yu, C. C., Wang, Y. M. & Su, C. H., 14 03 2023, 於: Biomaterials Science. 11, 6, p. 2177-2185 9 p.

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1 引文斯高帕斯（Scopus）

MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

Yen, W. C., Chang, K. P., Chen, C. Y., Huang, Y., Chen, T. W., Cheng, H. W., Yi, J. S., Cheng, C. C., Wu, C. C. & Wang, C. I., 12 06 2023, 於: Cancer Cell International. 23, 1, p. 112 112.

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1 引文斯高帕斯（Scopus）

Proton FLASH irradiation platform for small animal setup at Chang Gung Memorial Hospital

Hsiao, T.-Y., Wang, L.-K., Chen, T.-Y., Yu, C.-F., Pan, C.-Y., Wang, C.-C., Lin, C.-Y., Cho, I.-C., Niu, H. & Chen, C.-H., 2023, 於: arXiv. p. 1-11

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Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Wang, L. C., Chiou, P. Y., Hsu, Y. P., Lee, C. L., Hung, C. H., Wu, Y. H., Wang, W. J., Hsieh, G. L., Chen, Y. C., Chang, L. C., Su, W. P., Manoharan, D., Liao, M. C., Thangudu, S., Li, W. P., Su, C. H., Tian, H. K. & Yeh, C. S., 05 08 2023, 於: Nature Communications. 14, 1, p. 4709 4709.

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32 引文斯高帕斯（Scopus）

Radiotherapy enhances CXCR3^highCD8⁺ T cell activation through inducing IFNγ-mediated CXCL10 and ICAM-1 expression in lung cancer cells

Wang, C. L., Ho, A. S., Chang, C. C., Sie, Z. L., Peng, C. L., Chang, J. & Cheng, C. C., 06 2023, 於: Cancer Immunology Immunotherapy. 72, 6, p. 1865-1880 16 p.

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13 引文斯高帕斯（Scopus）

ROS-generating alginate-coated gold nanorods as biocompatible nanosonosensitisers for effective sonodynamic therapy of cancer

Loke, Y. L., Beishenaliev, A., Wang, P. W., Lin, C. Y., Chang, C. Y., Foo, Y. Y., Faruqu, F. N., Leo, B. F., Misran, M., Chung, L. Y., Shieh, D. B., Kiew, L. V., Chang, C. C. & Teo, Y. Y., 06 2023, 於: Ultrasonics Sonochemistry. 96, p. 106437 106437.

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8 引文斯高帕斯（Scopus）

Self-supervised neural network for phase retrieval in QDPC microscopy

Chen, Y. J., Vyas, S., Huang, H. M. & Luo, Y., 05 06 2023, 於: Optics Express. 31, 12, p. 19897-19908 12 p.

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1 引文斯高帕斯（Scopus）

Single-shot quantitative phase contrast imaging based on deep learning

Lin, Y. C., Luo, Y., Chen, Y. J., Chen, H. W., Young, T. H. & Huang, H. M., 01 07 2023, 於: Biomedical Optics Express. 14, 7, p. 3458-3468 11 p.

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2 引文斯高帕斯（Scopus）

Targeting M-MDSCs enhances the therapeutic effect of BNCT in the 4-NQO-induced murine head and neck squamous cell carcinoma model

Chang, C. H., Chen, C. J., Yu, C. F., Tsai, H. Y., Chen, F. H. & Chiang, C. S., 10 2023, 於: Frontiers in Oncology. 13, p. 1263873 1263873.

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3 引文斯高帕斯（Scopus）

2022

Decomposition of the weight fractions for modelling ridge filters in a proton wobbling nozzle

Hoang Oanh, L. D., Su, S. M., Lee, S. H., Huang, H. C., Chao, T. C., Aso, T. & Lee, C. C., 11 2022, 於: Radiation Physics and Chemistry. 200, 110324.

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3 引文斯高帕斯（Scopus）

Developing a Method to Estimate the Downstream Metabolite Signals from Hyperpolarized [1-¹³C]Pyruvate

Hsieh, C. Y., Sung, C. H., Shen, Y. L., Lai, Y. C., Lu, K. Y. & Lin, G., 08 2022, 於: Sensors. 22, 15, 5480.

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1 引文斯高帕斯（Scopus）

Engineering H₂O₂ and O₂ Self-Supplying Nanoreactor to Conduct Synergistic Chemiexcited Photodynamic and Calcium-Overloaded Therapy in Orthotopic Hepatic Tumors

Chen, Y. C., Liu, Y. J., Lee, C. L., Pham, K. Y., Manoharan, D., Thangudu, S., Su, C. H. & Yeh, C. S., 19 10 2022, 於: Advanced Healthcare Materials. 11, 20, 2201613.

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42 引文斯高帕斯（Scopus）

Focused Ultrasound-Induced Blood–Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson’s Disease

Lin, C. Y., Huang, C. Y., Chen, C. M. & Liu, H. L., 02 2022, 於: Pharmaceutics. 14, 2, 444.

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8 引文斯高帕斯（Scopus）

Improving Tirapazamine (TPZ) to Target and Eradicate Hypoxia Tumors by Gold Nanoparticle Carriers

Ajnai, G., Cheng, C. C., Kan, T. C., Lu, J. W., Rahayu, S., Chiu, A. & Chang, J., 04 2022, 於: Pharmaceutics. 14, 4, 847.

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19 引文斯高帕斯（Scopus）

Integration of Adenylate Kinase 1 with Its Peptide Conformational Imprint

Wu, C. H., Lin, C. Y., Lin, T. C. & Tai, D. F., 01 06 2022, 於: International Journal of Molecular Sciences. 23, 12, 6521.

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1 引文斯高帕斯（Scopus）

Magnetic, biocompatible FeCO₃ nanoparticles for T2-weighted magnetic resonance imaging of in vivo lung tumors

Thangudu, S., Yu, C. C., Lee, C. L., Liao, M. C. & Su, C. H., 12 2022, 於: Journal of Nanobiotechnology. 20, 1, 157.

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18 引文斯高帕斯（Scopus）

Peptide conformational imprints enhanced the catalytic activity of papain for esterification

Kanubaddi, K. R., Yang, C. L., Huang, P. Y., Lin, C. Y., Tai, D. F. & Lee, C. H., 16 08 2022, 於: Frontiers in Bioengineering and Biotechnology. 10, 943751.

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1 引文斯高帕斯（Scopus）

Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4’-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2’-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers

Kan, T. C., Lin, M. H., Cheng, C. C., Lu, J. W., Sheu, M. T., Ho, Y. S., Rahayu, S. & Chang, J., 04 2022, 於: Pharmaceutics. 14, 4, 839.

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3 引文斯高帕斯（Scopus）

Sorafenib suppresses radioresistance and synergizes radiotherapy-mediated CD8⁺ T cell activation to eradicate hepatocellular carcinoma

Cheng, C. C., Ho, A. S., Peng, C. L., Chang, J., Sie, Z. L., Wang, C. L., Chen, Y. L. & Chen, C. Y., 11 2022, 於: International Immunopharmacology. 112, 109110.

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15 引文斯高帕斯（Scopus）

2021

Ablative radiotherapy reprograms the tumor microenvironment of a pancreatic tumor in favoring the immune checkpoint blockade therapy

Lee, Y. H., Yu, C. F., Yang, Y. C., Hong, J.-H. & Chiang, C. S., 02 02 2021, 於: International Journal of Molecular Sciences. 22, 4, p. 1-14 14 p., 2091.

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16 引文斯高帕斯（Scopus）

Aristolochic acid-associated urinary tract cancers: an updated meta-analysis of risk and oncologic outcomes after surgery and systematic review of molecular alterations observed in human studies

Kang, Y.-C., Chen, M.-H., Klin, C.-Y. & Chen, Y.-T., 2021, 於: Therapeutic Advances in Drug Safety. 12

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12 引文斯高帕斯（Scopus）

Characterization of recurrent relevant genes reveals a novel role of rpl36a in radioresistant oral squamous cell carcinoma

Chen, T. W., Chang, K. P., Cheng, C. C., Chen, C. Y., Hong, S. W., Sie, Z. L., Cheng, H. W., Yen, W. C., Huang, Y., Liu, S. C. & Wang, C. I., 01 11 2021, 於: Cancers. 13, 22, 5623.

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7 引文斯高帕斯（Scopus）

Controversy of peptide cyclization from tripeptide

Lin, C. Y., Chakraborty, S., Wong, C. W. & Tai, D. F., 02 01 2021, 於: Molecules. 26, 2, 389.

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1 引文斯高帕斯（Scopus）

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 Tau_RD-DsRed SH-SY5Y Cells

Chiang, N. N., Lin, T. H., Teng, Y. S., Sun, Y. C., Chang, K. H., Lin, C. Y., Hsieh-Li, H. M., Su, M. T., Chen, C. M. & Lee-Chen, G. J., 15 12 2021, 於: Frontiers in Aging Neuroscience. 13, 758895.

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23 引文斯高帕斯（Scopus）

Generation of Brain Dual-Energy CT from Single-Energy CT Using Deep Learning

Liu, C. K., Liu, C. C., Yang, C. H. & Huang, H. M., 02 2021, 於: Journal of Digital Imaging. 34, 1, p. 149-161 13 p.

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18 引文斯高帕斯（Scopus）

Irradiation mediates IFNa and CXCl9 expression in non-small cell lung cancer to stimulate CD8⁺ t cells activity and migration toward tumors

Cheng, C. C., Chang, Y. F., Ho, A. S., Sie, Z. L., Chang, J. S., Peng, C. L. & Chang, C. C., 10 2021, 於: Biomedicines. 9, 10, 1349.

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12 引文斯高帕斯（Scopus）

Irradiation suppresses ifnγ-mediated pd-l1 and mcl1 expression in egfr-positive lung cancer to augment cd8⁺ t cells cytotoxicity

Wang, C.-I., Chang, Y. F., Sie, Z. L., Ho, A. S., Chang, J. S., Peng, C. L. & Cheng, C. C., 10 2021, 於: Cells. 10, 10, 2515.

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5 引文斯高帕斯（Scopus）

Local interleukin-12 treatment enhances the efficacy of radiation therapy by overcoming radiation-induced immune suppression

Yu, C. F., Chang, C. H., Wang, C. C., Hong, J. H., Chiang, C. S. & Chen, F. H., 09 2021, 於: International Journal of Molecular Sciences. 22, 18, 10053.

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5 引文斯高帕斯（Scopus）

Magnetic resonance spectroscopy for risk stratification of sonographically indeterminate ovarian neoplasms: Preliminary study

Lin, Y., Hsieh, C. Y., Huang, Y. L., Chen, K., Huang, Y. T., Wu, R. C., Huang, H. J., Chou, H. H., Chao, A., Lai, C. H. & Lin, G., 10 2021, 於: Diagnostics. 11, 10, 1847.

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3 引文斯高帕斯（Scopus）

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