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以LRRK2基因轉殖鼠模式,(G2385R)LRRK2帕金森病患者與無症狀帶因者的代謝體分析,探討LRRK2基因相關的帕金森病致病機轉
Weng, Yi-Hsin
(PI)
醫學系
研究計畫
:
國家科學及技術委員會(原科技部)
›
國家科學及技術委員會學術補助
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探索此專案觸及的研究主題。這些標籤是根據基礎獎勵/補助款而產生。共同形成了獨特的指紋。
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Biochemistry, Genetics and Molecular Biology
Mouse Model
100%
Transgenic Mouse
100%
Metabolomics
100%
Leucine-Rich Repeat
100%
Phosphotransferase
100%
Kinase
100%
Mouse
17%
Dopaminergic
17%
Time-of-Flight Mass Spectrometry
11%
Ultra High Performance Liquid Chromatography
11%
Human Study
11%
Normal Human
11%
Mitochondrial Permeability Transition Pore
11%
Liquid Chromatography-Mass Spectrometry
5%
Quantitative Technique
5%
Oxidative Stress
5%
Wild Type
5%
Genetics
5%
Genetic Risk
5%
FVB/N Mouse
5%
Molecular Weight
5%
Animal Experiment
5%
Metabolic Pathway
5%
Healthy Aging
5%
Medicine and Dentistry
Parkinson's Disease
100%
Leucine Rich Repeat Kinase 2
100%
Transgenic Mouse
100%
Metabolomics
100%
Asymptomatic Carrier
100%
Biological Marker
12%
Mitochondrial Permeability Transition Pore
8%
Human Study
8%
Ultra Performance Liquid Chromatography
8%
Disease Exacerbation
8%
Time-of-Flight Mass Spectrometry
8%
1,2,3,6 Tetrahydro 1 Methyl 4 Phenylpyridine
8%
Pharmacology, Toxicology and Pharmaceutical Science
Transgenic Mouse
100%
Mouse Model
100%
Parkinson's Disease
100%
Leucine Rich Repeat Kinase 2
100%
Dopamine Receptor Stimulating Agent
12%
Mouse
12%
Biological Marker
12%
Mitochondrial Permeability Transition Pore
8%
Disease
8%
1,2,3,6 Tetrahydro 1 Methyl 4 Phenylpyridine
8%
Human Study
8%
Disease Exacerbation
8%
Normal Human
8%
Ultra High Performance Liquid Chromatography
8%