A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

Ya Ling Chiu; Show An Chen; Jean Hong Chen; Ko Jie Chen; Hsin Lung Chen; Hsing Wen Sung

doi:10.1021/nn102644u

A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

Ya Ling Chiu
, Show An Chen
, Jean Hong Chen
, Ko Jie Chen
, Hsin Lung Chen^*
, Hsing Wen Sung

^*此作品的通信作者

National Tsing Hua University
Kun Shan University

研究成果: 期刊稿件 › 文章 › 同行評審

56 引文斯高帕斯（Scopus）

摘要

A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.

原文	英語
頁（從 - 到）	7467-7474
頁數	8
期刊	ACS Nano
卷	4
發行號	12
DOIs	https://doi.org/10.1021/nn102644u
出版狀態	已出版 - 28 12 2010
對外發佈	是

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title = "A dual-emission F{\"o}rster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment",

abstract = "A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive F{\"o}rster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.",

keywords = "F{\"o}rster resonance energy transfer, associating polyelectrolyte, dual emission, nanostructure transformation, pH-responsive nanoprobe, ratiometric imaging",

author = "Chiu, \{Ya Ling\} and Chen, \{Show An\} and Chen, \{Jean Hong\} and Chen, \{Ko Jie\} and Chen, \{Hsin Lung\} and Sung, \{Hsing Wen\}",

year = "2010",

month = dec,

day = "28",

doi = "10.1021/nn102644u",

language = "英语",

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T1 - A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

AU - Chiu, Ya Ling

AU - Chen, Show An

AU - Chen, Jean Hong

AU - Chen, Ko Jie

AU - Chen, Hsin Lung

AU - Sung, Hsing Wen

PY - 2010/12/28

Y1 - 2010/12/28

N2 - A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.

AB - A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.

KW - Förster resonance energy transfer

KW - associating polyelectrolyte

KW - dual emission

KW - nanostructure transformation

KW - pH-responsive nanoprobe

KW - ratiometric imaging

UR - https://www.scopus.com/pages/publications/78650757430

U2 - 10.1021/nn102644u

DO - 10.1021/nn102644u

M3 - 文章

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AN - SCOPUS:78650757430

SN - 1936-0851

VL - 4

SP - 7467

EP - 7474

JO - ACS Nano

JF - ACS Nano

IS - 12

ER -

A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

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