A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

Chia Wei Ting; Tsong Long Hwang; Ih Sheng Chen; Ming Hong Yen; Jih Jung Chen

doi:10.1002/cbdv.201100006

A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

Chia Wei Ting
, Tsong Long Hwang
, Ih Sheng Chen
, Ming Hong Yen^*
, Jih Jung Chen

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Kaohsiung Medical University
Tajen University

研究成果: 期刊稿件 › 文獻綜述 › 同行評審

19 引文斯高帕斯（Scopus）

摘要

A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC ₅₀ values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

原文	英語
頁（從 - 到）	99-105
頁數	7
期刊	Chemistry and Biodiversity
卷	9
發行號	1
DOIs	https://doi.org/10.1002/cbdv.201100006
出版狀態	已出版 - 01 2012

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10.1002/cbdv.201100006

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title = "A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses",

abstract = "A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC 50 values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.",

keywords = "Garcimultiflorone D, Garcinia multiflora, Inhibitors, Neutrophil pro-inflammatory responses, Phloroglucinol derivatives",

author = "Ting, \{Chia Wei\} and Hwang, \{Tsong Long\} and Chen, \{Ih Sheng\} and Yen, \{Ming Hong\} and Chen, \{Jih Jung\}",

year = "2012",

month = jan,

doi = "10.1002/cbdv.201100006",

language = "英语",

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T2 - Effects on neutrophil pro-inflammatory responses

AU - Ting, Chia Wei

AU - Hwang, Tsong Long

AU - Chen, Ih Sheng

AU - Yen, Ming Hong

AU - Chen, Jih Jung

PY - 2012/1

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N2 - A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC 50 values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

AB - A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC 50 values of 7.21±1.07 and 6.01±0.37μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

KW - Garcimultiflorone D

KW - Garcinia multiflora

KW - Inhibitors

KW - Neutrophil pro-inflammatory responses

KW - Phloroglucinol derivatives

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DO - 10.1002/cbdv.201100006

M3 - 文献综述

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AN - SCOPUS:84862928572

SN - 1612-1872

VL - 9

SP - 99

EP - 105

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 1

ER -

A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from garcinia multiflora: Effects on neutrophil pro-inflammatory responses

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