A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam; Shu Duan Jian; Tsong Long Hwang; Po Jen Chen; Hsin Yi Hung; Ping Chung Kuo; Tian Shung Wu

doi:10.1080/14786419.2019.1611809

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam, Shu Duan Jian, Tsong Long Hwang, Po Jen Chen, Hsin Yi Hung, Ping Chung Kuo^*, Tian Shung Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

研究成果: 期刊稿件 › 文章 › 同行評審

摘要

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

原文	英語
頁（從 - 到）	17-24
頁數	8
期刊	Natural Product Research
卷	35
發行號	1
DOIs	https://doi.org/10.1080/14786419.2019.1611809
出版狀態	已出版 - 2021

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© 2019 Informa UK Limited, trading as Taylor & Francis Group.

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10.1080/14786419.2019.1611809

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AU - Chen, Po Jen

AU - Hung, Hsin Yi

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2021

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KW - Menispermaceae

KW - anti-inflammatory

KW - elastase release

KW - superoxide anion generation

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AN - SCOPUS:85098629704

SN - 1478-6419

VL - 35

SP - 17

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JO - Natural Product Research

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IS - 1

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A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

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