A simple pumpfree HEPG2 liver cells spheroid amalgamation platform via gravity driving force

Shih Mo Yang, Chun Yen Lin, Shilpa Sivashankar, Srinivasu Valagerahally Puttaswamy, Hwan You Chang, Long Hsu, Cheng Hsien Liu

研究成果: 圖書/報告稿件的類型會議稿件同行評審

摘要

We present a simple pumpless microfluidics design to pair 3D artificial liver tissue. This design concept could pair two or more 3D spheroids with green approach for investigating artificial tissue cell-cell interaction. All the operation process, HepG2 cells spheroid formation and pairing, is accomplished on this chip within two days. The gravity force is applied to drive the 250μm diameter liver spheroid moving and no external power is required. Avoiding the hydrodynamic pressure damage for the assembled HepG2 cells caused by syringe pump is its unique advantage. This mimetic liver labchip is developed to hepatotoxicity assay with 3D liver tissue in the future.

原文英語
主出版物標題15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
頁面1017-1019
頁數3
出版狀態已出版 - 2011
對外發佈
事件15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, 美國
持續時間: 02 10 201106 10 2011

出版系列

名字15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
2

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
國家/地區美國
城市Seattle, WA
期間02/10/1106/10/11

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