A specific base transition occurs on replicating hepatitis delta virus RNA

Guangxiang Luo; Mei Chao; Sen Yung Hsieh; Camille Sureau; Kazuko Nishikura; John Taylor

A specific base transition occurs on replicating hepatitis delta virus RNA

Guangxiang Luo, Mei Chao, Sen Yung Hsieh, Camille Sureau, Kazuko Nishikura, John Taylor^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

228 引文斯高帕斯（Scopus）

摘要

Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

原文	英語
頁（從 - 到）	1021-1027
頁數	7
期刊	Journal of Virology
卷	64
發行號	3
出版狀態	已出版 - 1990
對外發佈	是

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title = "A specific base transition occurs on replicating hepatitis delta virus RNA",

abstract = "Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.",

author = "Guangxiang Luo and Mei Chao and Hsieh, {Sen Yung} and Camille Sureau and Kazuko Nishikura and John Taylor",

year = "1990",

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T1 - A specific base transition occurs on replicating hepatitis delta virus RNA

AU - Luo, Guangxiang

AU - Chao, Mei

AU - Hsieh, Sen Yung

AU - Sureau, Camille

AU - Nishikura, Kazuko

AU - Taylor, John

PY - 1990

Y1 - 1990

N2 - Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

AB - Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.

UR - http://www.scopus.com/inward/record.url?scp=0025255969&partnerID=8YFLogxK

M3 - 文章

C2 - 2304136

AN - SCOPUS:0025255969

SN - 0022-538X

VL - 64

SP - 1021

EP - 1027

JO - Journal of Virology

JF - Journal of Virology

IS - 3

ER -

A specific base transition occurs on replicating hepatitis delta virus RNA

摘要

UN SDG

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