Aberrant expression and possible involvement of the leptin receptor in bladder cancer

Shyng Shiou F. Yuan*, Yueh Fang Chung, Hsiao Wen Chen, Kun Bow Tsai, Hsueh Ling Chang, Chun Hsiung Huang, Jinu Huang Su

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

Objectives. To explore the expression patterns and possible involvement of leptin and its receptor in the pathogenesis of urinary bladder cancer, with a focus on transitional cell carcinoma. Methods. Using reverse transcription-polymerase chain reaction, immunoblotting, and immunohistochemistry techniques, we correlated the expression patterns of leptin and its receptor with the occurrence of transitional cell carcinoma. We also applied transient transfection followed by BrdU labeling and immunofluorescent staining to address the effect of the leptin receptor on bladder cancer cell growth. Results. Although leptin was not detected in the bladder tissue specimens, a decreased expression of the leptin receptor was observed in most cancer tissue specimens we analyzed. Furthermore, the forced expression of the leptin receptor in T24 bladder cancer cells prevented them from entering the S phase. Conclusions. Our data demonstrated for the first time that the leptin receptor is aberrantly expressed in bladder cancer tissue and is possibly involved in the carcinogenesis of bladder cancer.

原文英語
頁(從 - 到)408-413
頁數6
期刊Urology
63
發行號2
DOIs
出版狀態已出版 - 02 2004

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