Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana

An Shen Lin, Chia Rong Lin, Ying Chi Du, Tilo Lübken, Michael Y. Chiang, I. Hsiao Chen, Chin Chung Wu, Tsong Long Hwang, Shu Li Chen, Ming Hong Yen, Fang Rong Chang*, Yang Chang Wu

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

33 引文 斯高帕斯(Scopus)

摘要

Four new diterpenes, acasiane A (1), acasiane B (2), farnesirane A (3), and farnesirane B (4), along with three known diterpenes (5-7), two triterpenes (8 and 9), and eight flavonoids (10-17) were isolated from the roots of Acacia farnesiana. The structures and relative configurations of these compounds were determined by various spectroscopic and x-ray analyses. All isolated compounds were evaluated for their in vitro cytotoxic activities against six human cancer cell lines (Hep G2, Hep 3B, MDA-MB-231, MCF-7, A549, and Ca9-22) with the MTT method. Betulinic acid (8) displayed moderate cytotoxicity (1.70-5.74 μg/mL) towards five human cancer cell lines and the flavonoids had slight effects. In addition, 8, diosmetin (13), and 3′,4′,5-trihydroxy-7-methoxyflavone (15) slightly inhibited superoxide anion generation or elastase release by human neutrophils, indicating moderate anti-inflammatory activities.

原文英語
頁(從 - 到)256-261
頁數6
期刊Planta Medica
75
發行號3
DOIs
出版狀態已出版 - 02 2009

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