TY - JOUR
T1 - Acute Bronchitis and Bronchiolitis Infection in Children with Asthma and Allergic Rhinitis
T2 - A Retrospective Cohort Study Based on 5,027,486 Children in Taiwan
AU - Sung, Fung Chang
AU - Wei, Chang Ching
AU - Muo, Chih Hsin
AU - Tsai, Shan P.
AU - Chen, Chao W.
AU - Hsieh, Dennis P.H.
AU - Chen, Pei Chun
AU - Lu, Chung Yen
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/3/22
Y1 - 2023/3/22
N2 - This study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts with and without AR (N = 1,062,903, each) matched by sex and age. By the end of 2016, the asthma cohort had the highest bronchitis incidence, AR and non-asthma cohorts followed, and the lowest in the non-AR cohort (525.1, 322.4, 236.0 and 169.9 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratios (aHRs) of bronchitis were 1.82 (95% confidence interval (CI), 1.80–1.83) for the asthma cohort and 1.68 (95% CI, 1.68–1.69) for the AR cohort, relative to the respective comparisons. The bronchiolitis incidence rates for these cohorts were 42.7, 29.5, 28.5 and 20.1 per 1000 person-years, respectively. The aHRs of bronchiolitis were 1.50 (95% CI, 1.48–1.52) for the asthma cohort and 1.46 (95% CI, 1.45–1.47) for the AR cohort relative to their comparisons. The CABs incidence rates decreased substantially with increasing age, but were relatively similar for boys and girls. In conclusion, children with asthma are more likely to develop CABs than are children with AR.
AB - This study evaluated the risks of childhood acute bronchitis and bronchiolitis (CABs) for children with asthma or allergic rhinitis (AR). Using insurance claims data of Taiwan, we identified, from children of ≤12 years old in 2000–2016, cohorts with and without asthma (N = 192,126, each) and cohorts with and without AR (N = 1,062,903, each) matched by sex and age. By the end of 2016, the asthma cohort had the highest bronchitis incidence, AR and non-asthma cohorts followed, and the lowest in the non-AR cohort (525.1, 322.4, 236.0 and 169.9 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratios (aHRs) of bronchitis were 1.82 (95% confidence interval (CI), 1.80–1.83) for the asthma cohort and 1.68 (95% CI, 1.68–1.69) for the AR cohort, relative to the respective comparisons. The bronchiolitis incidence rates for these cohorts were 42.7, 29.5, 28.5 and 20.1 per 1000 person-years, respectively. The aHRs of bronchiolitis were 1.50 (95% CI, 1.48–1.52) for the asthma cohort and 1.46 (95% CI, 1.45–1.47) for the AR cohort relative to their comparisons. The CABs incidence rates decreased substantially with increasing age, but were relatively similar for boys and girls. In conclusion, children with asthma are more likely to develop CABs than are children with AR.
KW - acute bronchitis and bronchiolitis
KW - allergic rhinitis
KW - asthma
KW - human respiratory syncytial virus
KW - Acute Disease
KW - Humans
KW - Male
KW - Bronchitis/epidemiology
KW - Bronchiolitis/epidemiology
KW - Taiwan/epidemiology
KW - Rhinitis, Allergic/epidemiology
KW - Female
KW - Retrospective Studies
KW - Asthma/epidemiology
KW - Child
UR - http://www.scopus.com/inward/record.url?scp=85151170278&partnerID=8YFLogxK
U2 - 10.3390/v15030810
DO - 10.3390/v15030810
M3 - 文章
C2 - 36992517
AN - SCOPUS:85151170278
SN - 1999-4915
VL - 15
JO - Viruses
JF - Viruses
IS - 3
M1 - 810
ER -