ALOX5AP genetic variants and risk of atherothrombotic stroke in the Taiwanese population

Jiann Der Lee, Tsong-Hai Lee, Yen Chu Huang, Yeu Jhy Chang, Chien Hung Chang, Huan Lin Hsu, Ya Hui Lin, Chih Ying Wu, Meng Lee, Ying Chih Huang, Shan Jin Ryu, Kuang Ming Hsiao*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

We explored the role of variants of the arachidonate 5-lipoxygenase- activating protein (ALOX5AP) gene as factors for atherothrombotic stroke (ATS). A HapMap-based haplotype-tagging single nucleotide polymorphism (htSNP) association study was conducted in an isolated Taiwanese population. Multivariate logistic regression analyses revealed that patients with the GG/CG genotype of rs4293222 and the AA/AG genotype of rs4360791 had a 1.61-fold (odds ratio [OR] = 1.61; 95% confidence interval [CI] = 1.02-2.56, p = 0.042) and a 1.69-fold (OR = 1.69; 95% CI = 1.00-2.86, p = 0.047) increased risk of ATS, compared with patients with the CC/GG genotype, respectively. The most common haplotype allele, GTA, was used as a reference when analyzing the association between the haplotypes related to rs4293222, rs10507391, rs12429692 and ATS. The combined frequencies of all minor variant alleles of the three selected htSNP were associated with a 44% decreased risk of ATS (OR = 0.56; 95% CI = 0.37-0.84, p = 0.005). This study provides preliminary evidence suggesting that genetic polymorphisms of ALOX5AP are associated with ATS.

原文英語
頁(從 - 到)1634-1638
頁數5
期刊Journal of Clinical Neuroscience
18
發行號12
DOIs
出版狀態已出版 - 12 2011

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