Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance

Yu Chia Hsieh; Lin Hui Su; Mei Hua Hsu; Cheng Hsun Chiu

doi:10.1111/2049-632x.12018

Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance

Yu Chia Hsieh
, Lin Hui Su
, Mei Hua Hsu
, Cheng Hsun Chiu^*

^*此作品的通信作者

Chang Gung Memorial Hospital

研究成果: 期刊稿件 › 文章 › 同行評審

5 引文斯高帕斯（Scopus）

摘要

Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T

原文	英語
頁（從 - 到）	84-88
頁數	5
期刊	Pathogens and Disease
卷	67
發行號	1
DOIs	https://doi.org/10.1111/2049-632x.12018
出版狀態	已出版 - 02 2013

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10.1111/2049-632x.12018

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abstract = "Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T",

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AU - Hsieh, Yu Chia

AU - Su, Lin Hui

AU - Hsu, Mei Hua

AU - Chiu, Cheng Hsun

PY - 2013/2

Y1 - 2013/2

N2 - Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T

AB - Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae. T

KW - Penicillin-binding protein

KW - Streptococcus pneumoniae

KW - β-lactam resistance

UR - https://www.scopus.com/pages/publications/84878151040

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IS - 1

ER -

Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance

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