Altered expression of imprinted genes in patients with cytogenetically normal-acute myeloid leukemia: Implications for leukemogenesis and survival outcomes

Ming Yu Yang, Cheng Ming Hsu*, Pai Mei Lin, Chao Hui Yang, Ming Luen Hu, I. Ya Chen, Sheng Fung Lin*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Genomic imprinting, an epigenetic mechanism that regulates gene expression from parental chromosomes, holds substantial relevance in multiple cancers, including hemato-poietic malignancies. In the present study, the expression of a panel of 16 human imprinted genes in bone marrow samples from 64 patients newly diagnosed with cytogenetically normal-acute myeloid leukemia (CN-AML) were examined alongside peripheral blood samples from 85 healthy subjects. The validated findings of the present study revealed signifi-cant upregulation of seven genes [COPI coat complex subunit gamma 2 (COPG2), H19 imprinted maternally expressed transcript (H19), insulin like growth factor 2 (IGF2), PEG3 antisense RNA 1 (PEG3-AS1), DNA primase subunit 2 (PRIM2), solute carrier family 22 member 3 SLC22A3 and Zinc finger protein 215 (ZNF215)] in patients with CN-AML (P<0.001). Notably, the expression level of H19 exhibited an inverse association with the survival duration of the patients (P=0.018), establishing it as a predictive marker for two- and five-year survival in patients with CN-AML. Kaplan-Meier analysis demonstrated that patients with lower H19 expression had superior two- and five-year survival rates compared with those with higher H19 expression. The results of the present study highlighted the association between loss of imprinting and leukemogenesis in CN-AML, underscoring the significance of H19 imprinting loss as a prognostic indicator for unfavorable two- and five-year survival in CN-AML patients.

原文英語
文章編號94
頁(從 - 到)94
期刊Molecular and Clinical Oncology
19
發行號6
DOIs
出版狀態已出版 - 01 12 2023

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Copyright: © Yang et al.

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