Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder

Yu Fu Chen, Chih Yu Tsao, Yuh Tarng Chen, Ho Ching Chang, Wai Yu Li, Jui Lin Chiang, Chien Fu Fred Chen, Chia Hsiang Chen, Susan Shur Fen Gau, Kuang Yung Lee, Li Jen Lee, Yu Chun Wang*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Olfactory dysfunction has been observed in patients with Autism Spectrum Disorder (ASD). A microdeletion at the 8p23 terminal regions of chromosome 8p23 was identified in a Taiwanese patient with ASD, suggesting a potential association with mutations in the DLGAP2 gene. DLGAP2 is expressed in the olfactory bulb in rodents. The current study investigated olfactory phenotypes of Dlgap2 mutant mice. The results indicated that odor detection capabilities were comparable between wild-type (WT) and Dlgap2 mutant mice. However, homozygous mutant (Homo) mice showed less interest in sniffing odors of banana and almond but greater sniffing activity in response to bedding from unfamiliar cages. Notably, exposure to banana odor elicited significant c-fos expression in most olfaction-related brain regions of WT mice, while Homo mice did not show much increase in c-fos levels in major olfactory areas, which may correlate with their diminished sniffing behavior. Bedding stimuli induced pronounced c-fos expression in WT brains and some olfaction-related regions, including the olfactory bulb, amygdala, hypothalamus, and medial prefrontal cortex, in Homo mice. These mutants may still process olfactory signals from the bedding through a relatively narrow channel, which might elicit their interest, leading to increased sniffing behaviors that may compensate for their olfactory deficits. The DLGAP2 protein was absent in the olfactory bulb of Homo mice, and the levels of PSD95 and CaMKIIβ were also affected, indicating alterations in synaptic transmission and signaling within the olfactory system. This study evaluated olfactory perception in a mouse model of ASD, which may advance diagnostic and therapeutic strategies.

原文英語
文章編號115365
期刊Behavioural Brain Research
480
DOIs
出版狀態已出版 - 05 03 2025
對外發佈

文獻附註

Publisher Copyright:
© 2024 Elsevier B.V.

指紋

深入研究「Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder」主題。共同形成了獨特的指紋。

引用此