Amides with anti-platelet aggregation activity from Piper taiwanense

Ih Sheng Chen; Yu Chang Chen; Chang Hui Liao

doi:10.1016/j.fitote.2007.04.009

Amides with anti-platelet aggregation activity from Piper taiwanense

Ih Sheng Chen^*
, Yu Chang Chen
, Chang Hui Liao

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Kaohsiung Medical University

研究成果: 期刊稿件 › 文章 › 同行評審

19 引文斯高帕斯（Scopus）

摘要

Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC₅₀ value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC₅₀ values of 17.3 and 17.4 μM, respectively.

原文	英語
頁（從 - 到）	414-419
頁數	6
期刊	Fitoterapia
卷	78
發行號	6
DOIs	https://doi.org/10.1016/j.fitote.2007.04.009
出版狀態	已出版 - 09 2007

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10.1016/j.fitote.2007.04.009

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@article{fd5c9b83f315448d855af24c8647443a,

title = "Amides with anti-platelet aggregation activity from Piper taiwanense",

abstract = "Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.",

keywords = "Anti-platelet aggregation, Cinnamoylpyrrolidine, N-benzoyltyramine, Piper taiwanense, Taiwanamides",

author = "Chen, \{Ih Sheng\} and Chen, \{Yu Chang\} and Liao, \{Chang Hui\}",

year = "2007",

month = sep,

doi = "10.1016/j.fitote.2007.04.009",

language = "英语",

volume = "78",

pages = "414--419",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Amides with anti-platelet aggregation activity from Piper taiwanense

AU - Chen, Ih Sheng

AU - Chen, Yu Chang

AU - Liao, Chang Hui

PY - 2007/9

Y1 - 2007/9

N2 - Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.

AB - Three new amides, taiwanamides A-C (1-3), and two known amides, 1-cinnamoylpyrrolidine (4) and 1-(m-methoxycinnamoyl)pyrrolide (5), have been isolated from the stem of Piper taiwanense. The structures of the new amides were determined by spectral analyses. These five amides exhibited inhibitory activity of platelet aggregation in vitro. Taiwanamide C (3) owned the most potent inhibition activity of platelet aggregation induced by collagen showing IC50 value as 8.9 μM. Taiwanamide B (2) and 1-(m-methoxycinnamoyl)pyrrolide (5) exhibited IC50 values of 17.3 and 17.4 μM, respectively.

KW - Anti-platelet aggregation

KW - Cinnamoylpyrrolidine

KW - N-benzoyltyramine

KW - Piper taiwanense

KW - Taiwanamides

UR - https://www.scopus.com/pages/publications/34548027737

U2 - 10.1016/j.fitote.2007.04.009

DO - 10.1016/j.fitote.2007.04.009

M3 - 文章

C2 - 17590283

AN - SCOPUS:34548027737

SN - 0367-326X

VL - 78

SP - 414

EP - 419

JO - Fitoterapia

JF - Fitoterapia

IS - 6

ER -

Amides with anti-platelet aggregation activity from Piper taiwanense

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