An Increase of Blood Anti-β₂-glycoprotein-I Antibody Associates with Cerebral Hemorrhage in Patients without Antiphospholipid Antibody Syndrome

Although an increase of blood anti-beta2-glycoprotein I antibody (aβGPI) is known to raise the risk for cerebral ischemia in patients without anti-phospholipid antibody syndrome or systemic lupus erythrematosus, there is no case of cerebral hemorrhage mentioned yet. We reported 6 patients who suffered from nontraumatic cerebral hemorrhage who were identified to have an increase of aβGPI. The frequency of increased aβGPI in cerebral hemorrhage was 9.7%. Hematoma was predilected at putamen in patients with increased aβGPI. The activity of coagulation factors was normal. Multiple brain infarcts compatible with small artery occlusion were illustrated in all of them. Accordingly, cerebral hemorrhage may arise out of small artery vasculopathy in these patients. These results highlight a relationship between autoimmunity, such as aβGPI, and cerebral hemorrhage, especially in the case of an absence of traditional risk factor.