Analysis of polymorphisms in the promoter region and protein levels of interleukin-6 gene among gout patients

Pei Chien Tsai, Chung Jen Chen, Han Ming Lai, Shun Jen Chang*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Objective: To explore the associations between the polymorphisms and protein levels of interleukin-6 (IL-6) gene and gout disease. Methods: A total of 120 male gout patients and 184 healthy controls were enrolled. Each patient was matched with 1-2 gout-free controls by age within three years. Four polymorphisms in the promoter of IL-6 gene, including -597G/A, -572C/G, -373A(m)T(n), and -174G/C, and the IL-6 levels were analyzed. The clinical characteristics and biochemical markers in plasma were measured, including age of gout onset, duration of gout history, tophus number, gout attack frequency, uric acid, total cholesterol, triglycerides and creatinine. Results: The mean IL-6 level for gout patients was 9.80 (±11.76 pg/ml) which showed no significant difference from the controls (7.06±7.58 pg/ ml, p=0.230). When the IL-6 levels were dichotomized according to the median value (5 pg/ml), there were significantly higher proportions of the gout patients (59.66%) than controls (44%) with high IL-6 levels (OR=1.88, 95% CI=1.17-3.02, p=0.008). Unique genotype was found at polymorphisms -174G/C and -597G/A. Neither the polymorphisms -572C/G nor -373A(m)T(n) in the genotype or allele distributions showed a significant association related to clinical characteristics, biochemical markers, IL-6 levels or gout disease (all p>0.05). Conclusions: Those with gout disease have greater proportions of high IL-6 levels in plasma than controls, and there is no significant association between the four polymorphisms in the promoter region of IL-6 gene and gout disease.

原文英語
頁(從 - 到)841-847
頁數7
期刊Clinical and Experimental Rheumatology
26
發行號5
出版狀態已出版 - 09 2008
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