Androgen and androgen receptor signals jamming monocyte/macrophage functions in premalignant phase of livers

Wen Lung Ma*, Long Bin Jeng, Chun Chieh Yeh, Chawnshang Chang

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

9 引文 斯高帕斯(Scopus)

摘要

There is a widely discussed concept that chronic inflammation and repeated damage- repair cycles result in malignant transformation of the liver. Kupffer cells are the major host defending macrophages that reside in the liver. They are also considered as critical in episodes of cancer immune surveillance that wipe out liver malignancies, yet, turn into cancer assisting cells in certain conditions. Monocyte/macrophage population and cytokine profile hierarchization in hepatocellular carcinoma (HCC) has increased the curiosity to search for macrophage modulators. Androgenic signals [androgen/androgen receptors (A/AR)] play an important role in liver function and disease progression. Basic and clinical studies have revealed that A/AR might play a biphasic function in HCC progression. Whether A/AR work with TAM to further manipulate HCC progression is of great interest. In this review article, we will focus on the interaction of hepatocytes and monocytes/macrophages in preneoplastic/ inflammatory liver diseases, underlining A/AR actions.

原文英語
頁(從 - 到)155-159
頁數5
期刊BioMedicine (Netherlands)
2
發行號4
DOIs
出版狀態已出版 - 12 2012
對外發佈

指紋

深入研究「Androgen and androgen receptor signals jamming monocyte/macrophage functions in premalignant phase of livers」主題。共同形成了獨特的指紋。

引用此