Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo; Yi Hung Wu; Hsin Yi Hung; Sio Hong Lam; Guo Hao Ma; Liang Mou Kuo; Tsong Long Hwang; Daih Huang Kuo; Tian Shung Wu

doi:10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo
, Yi Hung Wu
, Hsin Yi Hung
, Sio Hong Lam
, Guo Hao Ma
, Liang Mou Kuo
, Tsong Long Hwang
, Daih Huang Kuo
, Tian Shung Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

National Cheng Kung University
National Chung Hsing University
Chang Gung Memorial Hospital
Chang Gung University
Tajen University

研究成果: 期刊稿件 › 文章 › 同行評審

30 引文斯高帕斯（Scopus）

摘要

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

原文	英語
文章編號	127224
期刊	Bioorganic and Medicinal Chemistry Letters
卷	30
發行號	13
DOIs	https://doi.org/10.1016/j.bmcl.2020.127224
出版狀態	已出版 - 01 07 2020

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© 2020 Elsevier Ltd

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10.1016/j.bmcl.2020.127224

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title = "Anti-inflammatory principles from Lindera aggregata",

abstract = "Four new sesquiterpenes (1{\textendash}4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.",

keywords = "Alkaloid, Anti-inflammatory, Benzenoid glycoside, Elastase release, Sesquiterpene, Superoxide anion generation",

author = "Kuo, \{Ping Chung\} and Wu, \{Yi Hung\} and Hung, \{Hsin Yi\} and Lam, \{Sio Hong\} and Ma, \{Guo Hao\} and Kuo, \{Liang Mou\} and Hwang, \{Tsong Long\} and Kuo, \{Daih Huang\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jul,

day = "1",

doi = "10.1016/j.bmcl.2020.127224",

language = "英语",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Anti-inflammatory principles from Lindera aggregata

AU - Kuo, Ping Chung

AU - Wu, Yi Hung

AU - Hung, Hsin Yi

AU - Lam, Sio Hong

AU - Ma, Guo Hao

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Kuo, Daih Huang

AU - Wu, Tian Shung

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

AB - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

KW - Alkaloid

KW - Anti-inflammatory

KW - Benzenoid glycoside

KW - Elastase release

KW - Sesquiterpene

KW - Superoxide anion generation

UR - https://www.scopus.com/pages/publications/85083885393

U2 - 10.1016/j.bmcl.2020.127224

DO - 10.1016/j.bmcl.2020.127224

M3 - 文章

C2 - 32359855

AN - SCOPUS:85083885393

SN - 0960-894X

VL - 30

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

M1 - 127224

ER -

Anti-inflammatory principles from Lindera aggregata

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