TY - JOUR
T1 - Anti-neutrophilic inflammatory secondary metabolites from the traditional Chinese medicine, Tiankuizi
AU - Lee, Chia Lin
AU - Hwang, Tsong Long
AU - Peng, Chieh Yu
AU - Chen, Chao Jung
AU - Chang, Yuan Shiun
AU - Wu, Yang Chang
PY - 2012/12
Y1 - 2012/12
N2 - Through bioassay-guided fractionation, thirteen compounds (1-13) were isolated from the dry root of Semiaquilegia adoxoides, known as Tiankuizi in traditional Chinese medicine (TCM). Among these, four benzoic acid derivatives (1, 2, 4, 5), one 4,6-dimethoxy-5-methyl-2H-pyran-2-one (10) and one 1,2,3-propanetriol (13) were found for the first time in S. adoxoides. This is the first record of compound 10 from a natural source. 4-Hydroxybenzoic acid (1) and 3,4-dihyroxybenzoic acid (2) showed selective inhibition against elastase release and superoxide anion generation, with IC50 values of 3.20 and 6.21 μg/mL, respectively. Compound 1 had 7-fold better activity than the positive control against elastase release induced by human neutrophils. Overall, our studies demonstrated Tiankuizi (S. adoxoides) as a potential TCM and isolates 1 and 2 as promising lead compounds for neutrophilic inflammatory diseases.
AB - Through bioassay-guided fractionation, thirteen compounds (1-13) were isolated from the dry root of Semiaquilegia adoxoides, known as Tiankuizi in traditional Chinese medicine (TCM). Among these, four benzoic acid derivatives (1, 2, 4, 5), one 4,6-dimethoxy-5-methyl-2H-pyran-2-one (10) and one 1,2,3-propanetriol (13) were found for the first time in S. adoxoides. This is the first record of compound 10 from a natural source. 4-Hydroxybenzoic acid (1) and 3,4-dihyroxybenzoic acid (2) showed selective inhibition against elastase release and superoxide anion generation, with IC50 values of 3.20 and 6.21 μg/mL, respectively. Compound 1 had 7-fold better activity than the positive control against elastase release induced by human neutrophils. Overall, our studies demonstrated Tiankuizi (S. adoxoides) as a potential TCM and isolates 1 and 2 as promising lead compounds for neutrophilic inflammatory diseases.
KW - Anti-neutrophilic inflammatory activity
KW - Ranunculaceae
KW - Semiaquilegia adoxoides
KW - Tiankuizi
UR - http://www.scopus.com/inward/record.url?scp=84875017430&partnerID=8YFLogxK
U2 - 10.1177/1934578x1200701221
DO - 10.1177/1934578x1200701221
M3 - 文章
C2 - 23413568
AN - SCOPUS:84875017430
SN - 1934-578X
VL - 7
SP - 1623
EP - 1626
JO - Natural Product Communications
JF - Natural Product Communications
IS - 12
ER -
