Antibacterial wound dressings made of differently concentrated Salvia Miltiorrhiza Bunge via electrospinning

This study is conducted with an attempt to explore the influences of PEO (2, 4, 6 wt%) and Salvia miltiorrhiza Bunge (100, 125, 150, and 175 mg/mL) over the antibacterial and other performances of wound dressings. The PEO/ Salvia miltiorrhiza Bunge mixtures are formed into wound dressings via the electrospinning. The scanning electron microscope (SEM) observation, fiber diameter analysis, water contact angle measurement, and antibacterial assay are performed to investigate the properties of wound dressings. The properties of nanofiber membranes are correlated with PEO concentration, and the antibacterial property of nanofiber membranes is dependent on the Salvia miltiorrhiza Bunge concentration, which makes the optimal Salvia miltiorrhiza Bunge/PEO ratio being 175/6. The optimal diameter of nanofibers is 239.00 ± 361 nm while the maximal diameter of inhibition zone is 11.50 mm. To sum up, the Salvia miltiorrhiza Bunge-loaded wound dressings exhibit the optimal water contact angle, antibacterial property, and nanofiber diameter.